INT22517

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Context Info
Confidence 0.03
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.18
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spleen 1
Mop3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 42 100.00 Very High Very High Very High
anesthesia 5 98.16 Very High Very High Very High
halothane 11 97.94 Very High Very High Very High
Perioperative pain 1 97.04 Very High Very High Very High
analgesia 1 92.40 High High
Abstinence syndrome 1 83.04 Quite High
Disease Link Frequency Relevance Heat
Post Operative Pain 1 97.04 Very High Very High Very High
Syndrome 1 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recombinant single-chain variable fragment (scFv) antibody to morphine-3-glucuronide (M3G) was produced using genetic material obtained from the spleen cells of mice immunised with a morphine-3-glucuronide-bovine serum albumin (M3G-BSA) conjugate.
Gene_expression (produced) of morphine-3-glucuronide in spleen associated with morphine
1) Confidence 0.03 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12738369 Disease Relevance 0 Pain Relevance 0.27
Production of a recombinant anti-morphine-3-glucuronide single-chain variable fragment (scFv) antibody for the development of a "real-time" biosensor-based immunoassay.
Gene_expression (Production) of morphine-3-glucuronide associated with morphine
2) Confidence 0.03 Published 2003 Journal J. Immunol. Methods Section Title Doc Link 12738369 Disease Relevance 0 Pain Relevance 0.34
Following morphine intake in humans, the metabolites morphine-3-glucuronide (M3G) and M6G are present in substantial concentrations and for longer periods than the parent drug.
Gene_expression (present) of morphine-3-glucuronide associated with morphine
3) Confidence 0.02 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17011617 Disease Relevance 0.10 Pain Relevance 1.04
Morphine-3-glucuronide (M3G) is the major metabolite of morphine and is present in the circulation of persons treated with morphine or abusing heroin.
Gene_expression (present) of Morphine-3-glucuronide associated with morphine
4) Confidence 0.01 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2333280 Disease Relevance 0.08 Pain Relevance 0.41
The present study determined the effect of halothane on the disposition of morphine by defining the effect of halothane anesthesia on the systemic, renal, and hepatic clearance of the parent compound, morphine, and on the generation of the primary metabolite, morphine-3-glucuronide (M3G) in the dog.
Gene_expression (generation) of morphine-3-glucuronide associated with anesthesia, halothane and morphine
5) Confidence 0.00 Published 1990 Journal Anesthesiology Section Abstract Doc Link 2301762 Disease Relevance 0 Pain Relevance 1.37

General Comments

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