INT225170

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 9 30.76 Quite Low
antagonist 6 22.36 Low Low
Opioid 13 21.92 Low Low
agonist 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 28 100.00 Very High Very High Very High
Cancer 32 97.92 Very High Very High Very High
Pancreatic Cancer 37 80.20 Quite High
Adenocarcinoma 5 74.12 Quite High
Injury 2 50.52 Quite High
Neuroblastoma 6 24.16 Low Low
Apoptosis 49 19.52 Low Low
Lymphatic System Cancer 4 9.04 Low Low
Leukemia 4 8.68 Low Low
Stress 16 6.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation that OGF down-regulated the phosphorylation of Rb on S795 is consistent with decreased Cdk2 kinase activity.
Regulation (regulated) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
1) Confidence 0.36 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.89 Pain Relevance 0
principally regulate the phosphorylation of the pRb.
Regulation (regulate) of Phosphorylation (phosphorylation) of pRb
2) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0
The hypophosphorylation of pRb proteins may depend on the inhibition of cyclin expression, however, this effect may also be
Spec (may) Regulation (depend) of Phosphorylation (hypophosphorylation) of pRb
3) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.08 Pain Relevance 0

General Comments

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