INT225189

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.27
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNE2) nucleoplasm (CCNE2) nucleus (CCNE2)
cell division (CCNE2)
Anatomy Link Frequency
HL-60 1
CCNE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 70.88 Quite High
Opioid 13 5.00 Very Low Very Low Very Low
narcan 9 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
long-term potentiation 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 195 98.62 Very High Very High Very High
Targeted Disruption 12 95.28 Very High Very High Very High
Breast Cancer 246 92.28 High High
Genomic Instability 4 90.76 High High
Apoptosis 23 86.24 High High
Inflammatory Breast Neoplasms 6 71.44 Quite High
Death 10 66.92 Quite High
Retinoblastoma 26 64.76 Quite High
Malignant Neoplastic Disease 12 64.68 Quite High
Disease 37 60.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two proteins codified by two different genes but with high homology, called cyclin E1 (formerly cyclin E) and cyclin E2 have been identified.173–177 Cyclin E2, like cyclin E1, associates with Cdk2 and activates its kinase activity at the G1/S boundary.176 Cyclin E2 shares 47% overall similarity to cyclin E1; whether its structural features outside the conserved regions reveal unique functions is unknown.176
Cyclin E2 Binding (activity) of
1) Confidence 0.10 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.70 Pain Relevance 0
Among molecules regulating the p53 and RB tumor suppressor pathways, mutation of p53, overexpression of cyclin D1b, LMW cyclin E are apparently associated with poor clinical outcome of patients.
LMW cyclin E Binding (associated) of associated with cancer
2) Confidence 0.09 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.24 Pain Relevance 0.10
Hence we need to group the genes CDK2, CYCE together as one cluster, and the ORC genes as another.
CYCE Binding (group) of
3) Confidence 0.07 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0
Based on our understanding of the mechanisms of DMSO and ATRA signaling in HL-60 cells, we know that the point at which these pathways converge is at the G1-S phase transition point controlled by the cyclin dependent kinase complex of Cyclin E and CDK2.
Cyclin E Binding (complex) of in HL-60
4) Confidence 0.06 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.21 Pain Relevance 0
OGF does not affect the cyclin E/Cdk2 complex
cyclin E Neg (not) Binding (complex) of
5) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox