INT225215

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
BxPC-3 2
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 42.32 Quite Low
imagery 31 29.96 Quite Low
fifth nerve 2 22.48 Low Low
trigeminal ganglion 2 16.16 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Meningioma 91 99.24 Very High Very High Very High
Neurofibromatosis 2 9 89.52 High High
Cancer 60 85.16 High High
Malignant Neoplastic Disease 5 82.56 Quite High
Death 16 50.00 Quite Low
Pancreatic Cancer 15 50.00 Quite Low
Dna Damage 1 36.88 Quite Low
Spinal Cord Compression 1 34.52 Quite Low
Paraparesis 1 32.12 Quite Low
Stress 2 26.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the synergy we observed between Nf2 and p16Ink4 mutations in meningioma development reflects the concomitant loss of two regulators of CDK4 activity resulting in cyclin D1 activation.
Negative_regulation (loss) of Positive_regulation (activation) of cyclin D1 associated with meningioma
1) Confidence 0.13 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.22 Pain Relevance 0
More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.
Negative_regulation (inhibitors) of Positive_regulation (increase) of Cyclin D1 in BxPC-3
2) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.12 Pain Relevance 0

General Comments

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