INT225216

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.16
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 62 78.64 Quite High
Spinal cord 8 5.00 Very Low Very Low Very Low
trigeminal ganglion 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
fifth nerve 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 76 100.00 Very High Very High Very High
Meningioma 182 99.28 Very High Very High Very High
Carcinoma 2 94.60 High High
Liver Cancer 4 92.56 High High
Osteoma 4 91.88 High High
Neurofibromatosis 2 18 90.72 High High
Congenital Anomalies 4 84.36 Quite High
Hydrocephalus 8 78.16 Quite High
Hyperplasia 8 5.00 Very Low Very Low Very Low
Metaplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these data indicate that in the mouse homozygous inactivation of p16ink4 tumor suppressor gene, with retained p19Arf function, synergizes with Nf2 loss in meningioma initiation, but not in meningioma progression.


Negative_regulation (synergizes) of Negative_regulation (retained) of p19Arf associated with meningioma and cancer
1) Confidence 0.42 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.57 Pain Relevance 0.08
Altogether, these data indicate that in the mouse homozygous inactivation of p16ink4 tumor suppressor gene, with retained p19Arf function, synergizes with Nf2 loss in meningioma initiation, but not in meningioma progression.


Negative_regulation (synergizes) of Negative_regulation (inactivation) of p16ink4 associated with meningioma and cancer
2) Confidence 0.42 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.59 Pain Relevance 0.08

General Comments

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