INT225224

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.40
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Nf2) nucleolus (Nf2) plasma membrane (Nf2)
cytoskeleton (Nf2) nucleus (Nf2) protein complex (Nf2)
Anatomy Link Frequency
plaque 1
Nf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 12 88.64 High High
Central nervous system 6 80.44 Quite High
Inflammation 3 47.48 Quite Low
cva 3 46.60 Quite Low
imagery 93 19.76 Low Low
trigeminal ganglion 6 5.00 Very Low Very Low Very Low
fifth nerve 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurofibromatosis 2 27 100.00 Very High Very High Very High
Cancer 114 99.92 Very High Very High Very High
Meningioma 273 99.40 Very High Very High Very High
Hyperostosis 6 94.52 High High
Targeted Disruption 9 92.72 High High
Central Nervous System Cancer 6 80.72 Quite High
Hyperplasia 12 67.20 Quite High
Recurrence 3 57.68 Quite High
Chronic Renal Failure 3 51.32 Quite High
Chromosome Aberrations 3 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The higher frequency of en plaque meningiomas in our mouse model is likely caused by the multifocality of Nf2 inactivation induced by diffusion in the subarachnoid space of the highly concentrated adCre vector suspension.
Positive_regulation (induced) of Nf2 in plaque associated with meningioma
1) Confidence 0.59 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.07 Pain Relevance 0.04
One of the genetic mechanisms underlying meningioma tumorigenesis includes early inactivation of the neurofibromatosis 2 (NF2) tumor suppressor gene (12, 18).
Positive_regulation (inactivation) of NF2 associated with neurofibromatosis 2, meningioma and cancer
2) Confidence 0.43 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.17 Pain Relevance 0.04
One of the genetic mechanisms underlying meningioma tumorigenesis includes early inactivation of the neurofibromatosis 2 (NF2) tumor suppressor gene (12, 18).
Positive_regulation (inactivation) of neurofibromatosis 2 associated with neurofibromatosis 2, meningioma and cancer
3) Confidence 0.43 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.16 Pain Relevance 0.04

General Comments

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