INT225225

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.43
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2b10)
Cyp2b10 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 98.56 Very High Very High Very High
Central nervous system 2 43.84 Quite Low
imagery 31 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
trigeminal ganglion 2 5.00 Very Low Very Low Very Low
fifth nerve 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Meningioma 91 99.62 Very High Very High Very High
Pancreatitis 11 98.56 Very High Very High Very High
Adenocarcinoma 27 98.46 Very High Very High Very High
Monosomy 1 97.72 Very High Very High Very High
Cancer 65 96.34 Very High Very High Very High
Chromosome Aberrations 1 91.24 High High
Recurrence 1 86.72 High High
Pancreatic Cancer 22 84.40 Quite High
Targeted Disruption 3 69.12 Quite High
Neurofibromatosis 2 9 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of the p16INK4a/p14ARF locus or monosomy of chromosome 9 was found in 17% of grade I, 52% of grade II, and 74% of grade III meningiomas (15) resulting in loss of p16 expression (23).
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with monosomy and meningioma
1) Confidence 0.29 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.37 Pain Relevance 0
Despite complex associations between tumor cells and PanINs, histological and molecular evidence suggests that PanINs can gradually progress to PDAC, bearing genetic traits such as Ras mutations, Cyclin D1 overexpression and loss of p16 expression [41,42].
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with adenocarcinoma and cancer
2) Confidence 0.16 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.06 Pain Relevance 0.27

General Comments

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