INT225229

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk6, Cdkn2a) nucleus (Cdk6, Cdkn2a) cell cycle (Cdk6, Cdkn2a)
nucleoplasm (Cdkn2a) cell differentiation (Cdk6) aging (Cdkn2a)
Cdk6 (Mus musculus)
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 27.32 Quite Low
imagery 31 24.64 Low Low
Spinal cord 4 5.00 Very Low Very Low Very Low
trigeminal ganglion 2 5.00 Very Low Very Low Very Low
fifth nerve 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 97.36 Very High Very High Very High
Cancer 38 96.12 Very High Very High Very High
Apoptosis 1 89.48 High High
Meningioma 91 86.12 High High
Monosomy 1 78.92 Quite High
Chromosome Aberrations 1 74.72 Quite High
Recurrence 1 70.20 Quite High
Targeted Disruption 3 52.60 Quite High
Neurofibromatosis 2 9 48.64 Quite Low
Brain Tumor 1 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p16INK4a/p14ARF locus encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in the mouse) by alternative first-exon usage and alternative reading frames (20). p16INK4a arrests cells in the G1 phase of the cell cycle by binding the cyclin-dependant kinases CDK4 and CDK6 and inhibiting their ability to phosphorylate and inactivate the retinoblastoma (RB1) family of tumor suppressor proteins (22). p14ARF acts through MDM2 to stabilize and activate the key checkpoint protein p53, which can arrest cells in both G1 and G2 or induce apoptosis (20).
CDK6 Binding (binding) of p16INK4a associated with cancer, apoptosis and retinoblastoma
1) Confidence 0.19 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox