INT225241

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.54
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (S100a7a) biological_process (S100a7a) cytoplasm (S100a7a)
Anatomy Link Frequency
nasal 2
MDA-MB-231 2
S100a7a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 95.48 Very High Very High Very High
cytokine 25 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Analgesic 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Buprenorphine 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 215 99.84 Very High Very High Very High
Necrosis 5 98.76 Very High Very High Very High
Cancer 160 98.28 Very High Very High Very High
Hypersensitivity 5 95.84 Very High Very High Very High
INFLAMMATION 10 95.48 Very High Very High Very High
Metastasis 90 93.32 High High
Noninfiltrating Intraductal Carcinoma 25 90.12 High High
Severe Combined Immunodeficiency 25 73.68 Quite High
Hypercalcemia 20 69.64 Quite High
Osteoporosis 15 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that S100A7 overexpression increases VEGF expression levels (8) and that downregulation of S100A7 decreases the expression of VEGF [14].
Positive_regulation (overexpression) of Gene_expression (overexpression) of S100A7
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.23 Pain Relevance 0
High VEGF levels have been detected in S100A7-overexpressing cells and these levels were correlated with increased tumor angiogenesis in human breast tumors [14].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of S100A7 associated with cancer and breast cancer
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.57 Pain Relevance 0
S100A7 has been shown to be overexpressed in breast cancers at sites of necrosis in tumor tissues [6], [8], as well as in the nasal fluid during allergic inflammatory reactions [27].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of S100A7 in nasal associated with necrosis, inflammation, cancer, hypersensitivity and breast cancer
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.09 Pain Relevance 0.05
The results are in agreement with previous studies which reported a 1.4-fold increase in invasiveness in S100A7-overexpressing MDA-MB-231 clones [28].
Positive_regulation (increase) of Gene_expression (overexpressing) of S100A7 in MDA-MB-231
4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.79 Pain Relevance 0.03
We have seen increased expression of S100A7 in two breast cancer cell lines following EGF stimulation.
Positive_regulation (increased) of Gene_expression (expression) of S100A7 associated with breast cancer
5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.86 Pain Relevance 0.04

General Comments

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