INT225249

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Src (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 10.56 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 129 98.92 Very High Very High Very High
Metastasis 54 92.76 High High
Noninfiltrating Intraductal Carcinoma 15 91.28 High High
Cancer 96 80.24 Quite High
Osteoporosis 9 79.12 Quite High
Severe Combined Immunodeficiency 15 73.20 Quite High
Basal And Squamous Cell Skin Cancer 6 71.64 Quite High
Psoriasis 6 69.68 Quite High
Reprotox - General 1 9 61.52 Quite High
Advanced Or Metastatic Breast Cancer 3 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated cell lines.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Src
1) Confidence 0.16 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.52 Pain Relevance 0
We observed a decrease in Src phosphorylation at Tyr416 in EGF-stimulated S100A7-downregulated cells as compared to the control cells (Figure 3C).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Src
2) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.18 Pain Relevance 0
We have seen decreased phosphorylation of c-Src at Tyr416 in S100A7-downregulated cell lines as compared to vector-transfected controls.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Src
3) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.81 Pain Relevance 0

General Comments

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