INT225253

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.36
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Src (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 78 100.00 Very High Very High Very High
Morphine 154 99.88 Very High Very High Very High
opioid receptor 168 94.48 High High
tolerance 56 84.44 Quite High
Analgesic 39 84.04 Quite High
metalloproteinase 2 79.92 Quite High
antagonist 16 63.36 Quite High
Glutamate 20 52.48 Quite High
Opioid 28 50.00 Quite Low
Periaqueductal grey 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 14 99.56 Very High Very High Very High
Cancer 156 95.04 Very High Very High Very High
Osteoporosis 3 83.60 Quite High
Severe Combined Immunodeficiency 5 77.68 Quite High
Breast Cancer 87 75.00 Quite High
Basal And Squamous Cell Skin Cancer 2 71.32 Quite High
Psoriasis 2 69.36 Quite High
Metastasis 142 55.76 Quite High
Recurrence 3 16.68 Low Low
Urological Neuroanatomy 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 10 nmol morphine dose promoted PKC-mediated phosphorylation of NMDAR1 Ser890 and Src-mediated phosphorylation of NMDAR2A Tyr1325.
Positive_regulation (promoted) of Phosphorylation (phosphorylation) of Src associated with kinase c and morphine
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.26
In particular, it has been shown that hydrogen peroxide, released as a consequence of LOX mediated catalysis, triggers the phosphorylation and activation of two key signal transduction pathway activators: Src and focal adhesion kinase (FAK).
Positive_regulation (triggers) of Phosphorylation (phosphorylation) of Src associated with adhesions
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.91 Pain Relevance 0.04
The 10 nmol morphine dose promoted PKC-mediated phosphorylation of NMDAR1 Ser890 and Src-mediated phosphorylation of NMDAR2A Tyr1325.
Positive_regulation (promoted) of Phosphorylation (phosphorylation) of Src associated with kinase c and morphine
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.25
In particular, it has been shown that hydrogen peroxide, released as a consequence of LOX mediated catalysis, triggers the phosphorylation and activation of two key signal transduction pathway activators: Src and focal adhesion kinase (FAK).
Positive_regulation (triggers) of Phosphorylation (phosphorylation) of Src associated with adhesions
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.91 Pain Relevance 0.04
In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated cell lines.
Positive_regulation (observed) of Phosphorylation (phosphorylation) of Src
5) Confidence 0.17 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.54 Pain Relevance 0

General Comments

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