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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Src (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 3 8.40 Low Low
Potency 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 44 96.36 Very High Very High Very High
Leukemia 26 92.36 High High
Disease 32 85.44 High High
Myeloid Leukemia 142 76.12 Quite High
Chronic Myeloid Leukemia 1 62.36 Quite High
Cancer 46 59.92 Quite High
Recurrence 7 38.80 Quite Low
Blast Crisis 23 30.16 Quite Low
Thrombocytopenia 8 28.80 Quite Low
Neutropenia 8 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other mechanisms of imatinib resistance may include: increased expression of Bcr-Abl through genomic amplification (Nicolini et al 2006), overexpression of Lyn or other Src-family tyrosine kinases (Donato et al 2003; Dai et al 2004), or overexpression of drug efflux proteins such as P-glycoprotein, which may decrease the intracellular concentration of imatinib in leukemic cells (Thomas et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Src
1) Confidence 0.20 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761189 Disease Relevance 0.06 Pain Relevance 0
EGFR expression combined with c-Src overexpression can initiate oncogenic transformation and marked migratory and invasive behavior in human breast cancer cells [23].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Src associated with breast cancer
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.18 Pain Relevance 0
Bcr-Abl positive cells cultured in the continuous presence of imatinib show a reduced Bcr-Abl protein level and an increase of expression of Src kinases (Donato et al 2003).
Positive_regulation (increase) of Gene_expression (expression) of Src
3) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.51 Pain Relevance 0

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