INT22526

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (RAE1) small molecule metabolic process (RAE1) carbohydrate metabolic process (RAE1)
transmembrane transport (RAE1) cytoplasm (RAE1) RNA binding (RAE1)
Anatomy Link Frequency
granulocytes 2
lymphocytes 2
RAE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 83.76 Quite High
rheumatoid arthritis 4 81.44 Quite High
Osteoarthritis 1 79.68 Quite High
Inflammation 2 79.16 Quite High
Arthritis 1 78.24 Quite High
Analgesic 1 76.20 Quite High
corticosteroid 1 62.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 91.32 High High
Disease 7 91.20 High High
Pain 2 83.76 Quite High
Rheumatoid Arthritis 4 81.44 Quite High
Osteoarthritis 1 79.68 Quite High
Crystal Associated Disease 1 78.40 Quite High
Arthritis 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, piroxicam inhibits both superoxide anion production and lysosomal enzyme release from human neutrophils and also inhibits IgM-rheumatoid factor production by human lymphocytes.
Negative_regulation (inhibits) of Gene_expression (production) of IgM-rheumatoid factor in lymphocytes
1) Confidence 0.37 Published 1983 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 6345166 Disease Relevance 0.72 Pain Relevance 0.31
Of the laboratory parameters examined, the responders, but not the nonresponders, demonstrated significant reductions (from postwashout values) in levels of IgM rheumatoid factor and C-reactive protein (CRP), along with significant increases in the number of circulating lymphocytes and decreases in the number of circulating granulocytes (P less than or equal to 0.05).
Negative_regulation (reductions) of Gene_expression (levels) of IgM rheumatoid factor in granulocytes
2) Confidence 0.00 Published 1990 Journal Arthritis Rheum. Section Abstract Doc Link 2302265 Disease Relevance 0.94 Pain Relevance 0.31

General Comments

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