INT225264

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL19) extracellular space (IL19) extracellular region (IL19)
Anatomy Link Frequency
CMT 93 1
MDA-MB-231 1
IL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 8 98.98 Very High Very High Very High
adenocard 2 95.60 Very High Very High Very High
cytokine 96 91.76 High High
Inflammation 98 62.76 Quite High
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 100.00 Very High Very High Very High
Apoptosis 9 89.48 High High
Breast Cancer 52 87.16 High High
Cancer 220 84.76 Quite High
Metastasis 41 78.44 Quite High
Disease 20 66.96 Quite High
INFLAMMATION 105 62.76 Quite High
Hypersensitivity 10 62.24 Quite High
Necrosis 2 59.32 Quite High
Skin Cancer 4 52.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1×105 MDA-MB-435, MIAPACA, OvCAR3 and CMT 93 cells were cultivated in 6 well plates for 24 h.
Positive_regulation (cultivated) of MDA in CMT 93
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.22 Pain Relevance 0
Conversely, pharmacologically inhibiting mechanotransduction with either blebbistatin or Y27632 resulted in an increase of OPN mRNA expression in both MDA231 and RWGT2 (data not shown).
Positive_regulation (increase) of MDA associated with mechanotransduction
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.12
The results are in agreement with previous studies which reported a 1.4-fold increase in invasiveness in S100A7-overexpressing MDA-MB-231 clones [28].
Positive_regulation (increase) of MDA in MDA-MB-231
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.80 Pain Relevance 0.03
The serum level of IL-19 in patients with stable asthma is increase compared with healthy controls [260].
Positive_regulation (increase) of IL-19 associated with asthma
4) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.57 Pain Relevance 0.19

General Comments

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