INT22532

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.59
Pain Relevance 8.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
liver 2
bile 1
body 1
Bsp (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 48 99.98 Very High Very High Very High
opiate 8 99.68 Very High Very High Very High
narcan 16 99.46 Very High Very High Very High
Bile 8 99.38 Very High Very High Very High
agonist 9 99.12 Very High Very High Very High
Central nervous system 1 99.12 Very High Very High Very High
Clonidine 31 97.32 Very High Very High Very High
anesthesia 3 96.76 Very High Very High Very High
tolerance 6 96.08 Very High Very High Very High
Angina 1 92.80 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 7 98.72 Very High Very High Very High
Status Epilepticus 5 98.04 Very High Very High Very High
Convulsion 5 94.56 High High
Angina 1 92.80 High High
Hypothermia 2 91.80 High High
Heart Rate Under Development 1 91.24 High High
Persistent Vegetative State 1 88.08 High High
Coma 1 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both drugs elevated plasma BSP levels similarly in tolerant and non-tolerant mice.
Positive_regulation (elevated) of BSP in plasma
1) Confidence 0.70 Published 1987 Journal Life Sci. Section Abstract Doc Link 3561168 Disease Relevance 0 Pain Relevance 1.90
Naloxone reversed morphine-induced elevation of plasma BSP levels.
Positive_regulation (elevation) of BSP in plasma associated with narcan and morphine
2) Confidence 0.70 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3973820 Disease Relevance 0.09 Pain Relevance 0.97
In bile duct-cannulated mice morphine increased BSP levels in plasma and liver whereas reducing the amount of dye eliminated in bile.
Positive_regulation (increased) of BSP in bile associated with bile and morphine
3) Confidence 0.41 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3973820 Disease Relevance 0.08 Pain Relevance 0.98
When given together at these doses, they caused BSP levels in plasma and liver to be raised.
Positive_regulation (caused) of BSP in liver
4) Confidence 0.41 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2873230 Disease Relevance 0 Pain Relevance 1.29
Levels of sulphobromophthalein (BSP) in plasma and liver were elevated by the opiate, morphine, and by the alpha 2-adrenoceptor agonist, clonidine.
Positive_regulation (elevated) of BSP in liver associated with agonist, opiate, clonidine and morphine
5) Confidence 0.41 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2873230 Disease Relevance 0 Pain Relevance 0.99
PTB-induced BSP appears to be safe and effective for refractory SE if it is started soon after failure of a BZD and PHT.
Positive_regulation (induced) of BSP associated with status epilepticus
6) Confidence 0.40 Published 1990 Journal Epilepsia Section Abstract Doc Link 2303014 Disease Relevance 0.93 Pain Relevance 0.23
Levels of sulphobromophthalein (BSP) in plasma and liver were elevated by the opiate, morphine, and by the alpha 2-adrenoceptor agonist, clonidine.
Positive_regulation (elevated) of BSP in plasma associated with agonist, opiate, clonidine and morphine
7) Confidence 0.14 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2873230 Disease Relevance 0 Pain Relevance 0.99
When given together at these doses, they caused BSP levels in plasma and liver to be raised.
Positive_regulation (caused) of BSP in plasma
8) Confidence 0.14 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2873230 Disease Relevance 0 Pain Relevance 1.29
BSP were derived from the 80-lead body surface map (BSM).
Positive_regulation (derived) of BSP in body
9) Confidence 0.04 Published 2003 Journal J Electrocardiol Section Abstract Doc Link 14716613 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

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