INT225342

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncoa6) enzyme binding (Ncoa6) protein complex (Ncoa6)
Anatomy Link Frequency
CAR 1
Ncoa6 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.00 Very High Very High Very High
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 192 99.62 Very High Very High Very High
Breast Cancer 64 98.96 Very High Very High Very High
Hepatotoxicity 8 98.12 Very High Very High Very High
Apoptosis 144 79.12 Quite High
Repression 32 71.20 Quite High
Obesity 40 62.44 Quite High
Cataract 8 60.24 Quite High
Microphthalmia 8 58.68 Quite High
Congenital Anomalies 8 52.88 Quite High
Necrosis 8 39.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, studies of NCoA6(TRBP) activity in cells deficient in DNA-PK indicate a marked reduction in NCoA6(TRBP)-mediated enhancement of GR activity, suggesting a role for DNA-PK in transcriptional activation [Ko and Chin, 2003].
Negative_regulation (reduction) of NCoA6
1) Confidence 0.49 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, the phenotypes may result not just from inhibition of NCoA6(ASC-2)-NR interaction, but also from inactivation of a number of receptors that bind DN1 in vivo.
Negative_regulation (inhibition) of NCoA6
2) Confidence 0.42 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.79 Pain Relevance 0
The in vivo data obtained from conditional knockout studies show that NCoA6(PRIP) deficiency in liver fails to alter acetaminophen-induced hepatotoxicity in mice pretreated with CAR ligands phenobarbital (PB) or TCPOBOP.
Negative_regulation (deficiency) of NCoA6 in CAR associated with targeted disruption, paracetamol and hepatotoxicity
3) Confidence 0.42 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.68 Pain Relevance 0.10
AIB3 is believed to be a 2001 amino acid protein, which differs from NCoA6 at their N-termini, where the first 88 amino acids of NCoA6 are replaced by 26 different amino acids in AIB3 (NCBI Accession # AF208277).
Negative_regulation (replaced) of NCoA6
4) Confidence 0.42 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.09 Pain Relevance 0
When a region of NCoA6(NRC) containing LxxLL-AD2 was expressed in mammalian cells, it was found to be only moderately active when expressed alone.
Negative_regulation (region) of NCoA6
5) Confidence 0.41 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The physical isolation of AIB3 cDNA and detailed studies may reveal some functional differences between the two.
Negative_regulation (isolation) of AIB3 cDNA
6) Confidence 0.41 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.09 Pain Relevance 0
Furthermore, an NCoA6 isoform lacking the inhibitory C-terminal STL region, but which retains LxxLL-1 and AD2, might be expected to be a more active isoform of NCoA6.
Negative_regulation (isoform) of NCoA6
7) Confidence 0.41 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
A second isoform of human NCoA6 has been identified and is referred to as AIB3 (Amplified in Breast Cancer 3).
Negative_regulation (referred) of NCoA6 associated with breast cancer
8) Confidence 0.36 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.10 Pain Relevance 0

General Comments

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