INT225355

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 2.98
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Set) nucleus (Set) protein complex (Set)
cytoplasm (Set)
Anatomy Link Frequency
Atlas 3
blood 1
brain 1
external 1
Set (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 124 99.98 Very High Very High Very High
anesthesia 5 83.00 Quite High
antagonist 39 69.36 Quite High
Potency 120 53.08 Quite High
Glutamate 105 50.00 Quite Low
adenocard 1 46.56 Quite Low
metalloproteinase 2 43.56 Quite Low
depression 11 25.72 Quite Low
agonist 124 21.60 Low Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 47 99.48 Very High Very High Very High
Myeloid Leukemia 28 93.28 High High
Cancer 64 90.08 High High
Leukemia 53 89.00 High High
Myelodysplastic Syndromes 4 85.52 High High
Disease 55 85.28 High High
Targeted Disruption 47 83.92 Quite High
Apoptosis 81 80.36 Quite High
Body Weight 16 78.44 Quite High
Carcinoma 11 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For Set IVA blood was collected, serum collected and blood filtrate prepared as described above after sacrifice of animals.
Gene_expression (blood) of Set in blood
1) Confidence 0.37 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2661047 Disease Relevance 0.77 Pain Relevance 0.08
NCoA6 has been shown to associate with at least three distinct coactivator complexes containing Set methyltransferases as core polypeptides.
Gene_expression (methyltransferases) of Set
2) Confidence 0.16 Published 2008 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2254332 Disease Relevance 0.26 Pain Relevance 0
The impact of these descriptors makes intuitive sense as active compounds such as benzoxazepines and benzamides (Figure 4) that are well represented in the training data set contain extended ?
Gene_expression (training) of set
3) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
Of the total experimental data set, 115,581 (80%) data points were used for the ANN training (Figure 6c,d); 14,448 (10%) data points were set aside for monitoring during ANN training and initiating early termination (Figure 6c,d).
Gene_expression (used) of set
4) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
To further optimize the set of descriptors, the least sensitive descriptor categories were systematically removed in an iterative process (Table 2 iterations 2?
Gene_expression (optimize) of set
5) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
The impact of these descriptors makes intuitive sense as active compounds such as benzoxazepines and benzamides (Figure 4) that are well represented in the training data set contain extended ?
Gene_expression (represented) of set
6) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
Of the total experimental data set, 115,581 (80%) data points were used for the ANN training (Figure 6c,d); 14,448 (10%) data points were set aside for monitoring during ANN training and initiating early termination (Figure 6c,d).
Gene_expression (used) of set
7) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
Selection of the Optimal Set of Descriptors of Chemical Structure
Gene_expression (Selection) of Set
8) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0
In conclusion, machine learning methods (ANN) were used to generate QSAR models from an HTS experimental data set in virtual screens of an external commercial compound collection for the purpose of enrichment of our local library for compounds with mGluR5 allosteric activity.
Gene_expression (experimental) of set in external
9) Confidence 0.16 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0.03
+APAP set was repeated using only probes showing?
Gene_expression (repeated) of set associated with paracetamol
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0 Pain Relevance 0.32
In the brain (Table S2), 1285 probe sets, corresponding to 978 genes, displayed statistically significant differences in expression between wildtype and mutant mice (per-probe-set false discovery rate of Q<0.05).
Gene_expression (expression) of set in brain
11) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
The full set of inferred gene annotations can be found in Table S2.
Gene_expression (found) of set
12) Confidence 0.07 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0
To differentiate among these three scenarios (and to infer missing annotation in the last case), we next examined the expression of trans-band targets in a second independent gene expression data set called the Gene Atlas [17].
Gene_expression (expression) of set in Atlas
13) Confidence 0.07 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.23 Pain Relevance 0
Whereas eQTL analysis was based on expression data from a single tissue across many strains of mice, the Gene Atlas data set measured expression of a single strain across many diverse anatomic tissues.
Gene_expression (expression) of set in Atlas associated with sprains and strains
14) Confidence 0.06 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.25 Pain Relevance 0
We next examined the Gene Atlas expression pattern of individual trans-band targets in this filtered set of trans-eQTL bands.
Spec (examined) Gene_expression (expression) of set in Atlas
15) Confidence 0.06 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.12 Pain Relevance 0
This translocation generates a fusion protein called BCR-ABL which
Gene_expression (generates) of translocation
16) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.34 Pain Relevance 0.03

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