INT225358

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Med1) nucleolus (Med1) nucleus (Med1)
DNA binding (Med1) transcription factor binding (Med1)
Anatomy Link Frequency
liver 4
Med1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 50.00 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Targeted Disruption 56 94.24 High High
Embryonic Lethality 8 91.52 High High
Cataract 1 89.44 High High
Microphthalmia 1 87.88 High High
Congenital Anomalies 1 82.08 Quite High
INFLAMMATION 49 50.00 Quite Low
Cancer 19 50.00 Quite Low
Hypolipidemia 2 50.00 Quite Low
Apoptosis 20 35.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditional deletion of PBP/MED1 gene in liver results in the abrogation of PPAR?
Negative_regulation (deletion) of Gene_expression (gene) of PBP in liver
1) Confidence 0.30 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
Conditional deletion of PBP/MED1 gene in liver results in the abrogation of PPAR?
Negative_regulation (deletion) of Gene_expression (gene) of MED1 in liver
2) Confidence 0.30 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.09 Pain Relevance 0
Both DN1 and DN2 caused repression of some NR-mediated target gene expression, which was found to be completely reversed by co-transfection of wild-type NCoA6(ASC-2), but not by co-expression of other coactivators such as TRAP220 or SRC-1.
Negative_regulation (repression) of Gene_expression (expression) of TRAP220 associated with repression
3) Confidence 0.16 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.97 Pain Relevance 0

General Comments

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