INT225365

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Sox9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 68.72 Quite High
Paracetamol 2 49.48 Quite Low
antagonist 2 12.28 Low Low
Pain 14 5.00 Very Low Very Low Very Low
backache 12 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Intervertebral Disk Degeneration 62 79.68 Quite High
Apoptosis 26 64.24 Quite High
Targeted Disruption 24 56.92 Quite High
Necrosis 1 50.48 Quite High
Hepatotoxicity 1 22.28 Low Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Low Back Pain 12 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factor Sox9, which is associated with chondrogenic differentiation and collagen II synthesis, is expressed throughout the disc structures during embryogenesis (Barrionuevo et al., 2006) and in the newborn AF (Gruber et al., 2005).
Sox9 Binding (associated) of
1) Confidence 0.28 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.15 Pain Relevance 0
Among these, Sox5, Sox6 and Sox9 are specifically implicated in chondrogenesis (Schepers et al., 2002), and all three seem to be important for disc development.
Sox9 Binding (implicated) of
2) Confidence 0.28 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.06 Pain Relevance 0
Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Sox9 Binding (enhance) of associated with shock
3) Confidence 0.20 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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