INT225365

Context Info Confidence 0.28 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.48 Pain Relevance 0.03

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9) extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)

Sox9 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 3 68.72 Paracetamol 2 49.48 antagonist 2 12.28 Pain 14 5.00 backache 12 5.00 Inflammation 3 5.00 palliative 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Shock 3 100.00 Intervertebral Disk Degeneration 62 79.68 Apoptosis 26 64.24 Targeted Disruption 24 56.92 Necrosis 1 50.48 Hepatotoxicity 1 22.28 Wound Healing 15 5.00 Low Back Pain 12 5.00 Stress 10 5.00 Pressure And Volume Under Development 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The transcription factor Sox9, which is associated with chondrogenic differentiation and collagen II synthesis, is expressed throughout the disc structures during embryogenesis (Barrionuevo et al., 2006) and in the newborn AF (Gruber et al., 2005).

Sox9 Binding (associated) of

1) Confidence 0.28 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.15 Pain Relevance 0

Among these, Sox5, Sox6 and Sox9 are specifically implicated in chondrogenesis (Schepers et al., 2002), and all three seem to be important for disc development.

Sox9 Binding (implicated) of

2) Confidence 0.28 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.06 Pain Relevance 0

Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].

Sox9 Binding (enhance) of associated with shock

3) Confidence 0.20 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

This test has worked.