INT225373

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.68
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cytip) cytoplasm (Cytip)
Anatomy Link Frequency
Appendix 1
Cytip (Mus musculus)
Pain Link Frequency Relevance Heat
backache 44 100.00 Very High Very High Very High
insula 11 95.56 Very High Very High Very High
Pain 22 89.32 High High
amygdala 1 81.44 Quite High
Thalamus 2 80.28 Quite High
Hippocampus 5 79.88 Quite High
Anterior cingulate 5 38.00 Quite Low
Neurotransmitter 20 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Lasting pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 46 100.00 Very High Very High Very High
Pain 32 89.32 High High
Shock 10 85.76 High High
Urological Neuroanatomy 8 65.84 Quite High
Disease 221 47.08 Quite Low
Targeted Disruption 112 46.56 Quite Low
Cancer 21 36.32 Quite Low
Apoptosis 54 31.40 Quite Low
Wound Healing 45 28.44 Quite Low
Breast Cancer 24 21.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To probe these processes further, we examined whether expression levels of specific DNA repair genes (Msh2, Msh3, Ogg1 and Cbp), previously shown to play important roles in CAG repeat instability [8,13,14,21,24-26], correlated with instability index measured in 16 tissues.
Spec (whether) Gene_expression (expression) of Cbp
1) Confidence 0.54 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Gene_expression (expression) of Cbp
2) Confidence 0.54 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Gene_expression (levels) of Cbp
3) Confidence 0.42 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
In agreement with these findings, and further validating the predictive power of our signature, protein levels of Msh2 (Figure 6B) and Cbp (data not shown) did not correlate with instability index.
Gene_expression (levels) of Cbp
4) Confidence 0.42 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
Thus, like CBP, p300 or TRAP220, NCoA6 appears to be an essential gene involved in the regulation of growth, development and cell survival.
Gene_expression (appears) of CBP
5) Confidence 0.15 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300
Gene_expression (/) of CBP
6) Confidence 0.15 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.09 Pain Relevance 0
Thus, liganded NRs bind members of the p160 family, which recruit CBP/p300 (and CBP bound p/CAF) to a target gene promoter.
Gene_expression (/) of CBP
7) Confidence 0.15 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
A side by side comparison between HC and CBP communities and Beckmann's resting state networks can be found in Figure A1 of Appendix.


Gene_expression (communities) of CBP in Appendix associated with backache
8) Confidence 0.09 Published 2010 Journal Frontiers in Neuroinformatics Section Body Doc Link PMC3013486 Disease Relevance 0.60 Pain Relevance 0.67

General Comments

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