INT225375

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.63
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cytip) cytoplasm (Cytip)
Anatomy Link Frequency
medial 1
posterior 1
Cytip (Mus musculus)
Pain Link Frequency Relevance Heat
backache 88 100.00 Very High Very High Very High
insula 22 98.32 Very High Very High Very High
Pain 37 96.24 Very High Very High Very High
Anterior cingulate 10 92.24 High High
amygdala 2 88.36 High High
Thalamus 4 87.20 High High
Hippocampus 3 86.80 High High
Lasting pain 20 5.00 Very Low Very Low Very Low
Anterior cingulate cortex 12 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 92 100.00 Very High Very High Very High
Urological Neuroanatomy 16 97.52 Very High Very High Very High
Pain 57 96.24 Very High Very High Very High
Disease 57 37.68 Quite Low
Targeted Disruption 34 37.16 Quite Low
Obesity 7 17.84 Low Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Negative_regulation (levels) of Cbp
1) Confidence 0.30 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
Chromatin immunoprecipitation assays (ChIP) indicate that p160 coactivators and CBP/p300 are recruited to NR target genes rapidly (30 min to 1 h) after ligand binding [Sharma and Fondell, 2002].
Negative_regulation (recruited) of CBP
2) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
This community appears to be altered in CBP patients because it does not include the insula and the posterior portion of the cingulate gyrus as it occurs in HC.
Negative_regulation (altered) of CBP in posterior associated with insula and backache
3) Confidence 0.05 Published 2010 Journal Frontiers in Neuroinformatics Section Body Doc Link PMC3013486 Disease Relevance 0.80 Pain Relevance 0.81
This community appears to be altered in CBP patients, because it extends to the precuneus and the medial frontal cortex in CBP patients, but does not include the orbito-frontal cortex as it occurs in HC.
Negative_regulation (altered) of CBP in medial associated with urological neuroanatomy and backache
4) Confidence 0.05 Published 2010 Journal Frontiers in Neuroinformatics Section Body Doc Link PMC3013486 Disease Relevance 0.83 Pain Relevance 0.46

General Comments

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