INT22540

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.56
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
brain 4
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 12 99.60 Very High Very High Very High
Bioavailability 13 93.16 High High
local anesthetic 1 91.20 High High
Hippocampus 1 86.64 High High
cINOD 5 83.52 Quite High
Inflammation 4 81.40 Quite High
Nucleus accumbens 1 75.76 Quite High
Dopamine 5 73.96 Quite High
monoamine 1 71.60 Quite High
Cancer pain 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
Fever 59 95.44 Very High Very High Very High
INFLAMMATION 8 81.40 Quite High
Diabetes Mellitus 5 79.32 Quite High
Increased Venous Pressure Under Development 2 76.64 Quite High
Cognitive Disorder 1 64.52 Quite High
Attention Deficit Hyperactivity Disorder 97 50.00 Quite Low
Aids-related Complex 2 36.28 Quite Low
Tic Disorders 7 29.28 Quite Low
Anxiety Disorder 13 28.64 Quite Low
Drug Dependence 1 27.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the KaD value of albumin binding of tryptophan in vivo in the rabbit brain microcirculation was reduced by ether anesthesia to a value of 2.1 +/- 0.4 mM.
Negative_regulation (value) of albumin Binding (binding) of in brain associated with anesthesia
1) Confidence 0.59 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0.35
In-vitro, fatty acid mixtures (FAs) inhibited the binding of flurbiprofen to rat serum albumin.
Negative_regulation (inhibited) of albumin Binding (binding) of
2) Confidence 0.45 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18088500 Disease Relevance 0.08 Pain Relevance 0.21
In contrast, the KaD value of albumin binding of tryptophan in vivo in the rabbit brain microcirculation was reduced by ether anesthesia to a value of 2.1 +/- 0.4 mM.
Negative_regulation (reduced) of albumin Binding (binding) of in brain associated with anesthesia
3) Confidence 0.43 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0.36
Bupivacaine reduced mepivacaine binding to albumin, but the degree of displacement was not significant.
Negative_regulation (reduced) of albumin Binding (binding) of
4) Confidence 0.30 Published 1984 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6478740 Disease Relevance 0 Pain Relevance 0.09
Binding to albumin prevents the rapid enzymatic inactivation of PGE2 [37,38], thus allowing it to reach a distant site.
Negative_regulation (prevents) of albumin Binding (Binding) of
5) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.34 Pain Relevance 0
Atomoxetine is highly protein bound, roughly 98%, specifically to albumin.8–10

Metabolism and elimination

Negative_regulation (elimination) of albumin Binding (bound) of
6) Confidence 0.13 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695220 Disease Relevance 0.06 Pain Relevance 0.33
Even though a small decrease in
albumin binding was observed (Fig.
8E), the decrease was not significant. 
Negative_regulation (decrease) of albumin Binding (binding) of
7) Confidence 0.08 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2596408 Disease Relevance 0 Pain Relevance 0
To decrease binding to albumin, Brader et al.19 recently synthesized octanoyl-N-Lys?
Negative_regulation (decrease) of albumin Binding (binding) of
8) Confidence 0.06 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0.08 Pain Relevance 0

General Comments

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