INT225400

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Med1) nucleolus (Med1) nucleus (Med1)
DNA binding (Med1) transcription factor binding (Med1)
Med1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 50.00 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 99.52 Very High Very High Very High
Embryonic Lethality 8 77.92 Quite High
Retinoblastoma 1 63.56 Quite High
Obesity 31 50.16 Quite High
INFLAMMATION 49 50.00 Quite Low
Cancer 19 50.00 Quite Low
Hypolipidemia 2 50.00 Quite Low
Liver Cancer 32 5.00 Very Low Very Low Very Low
Stress 20 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling requires PBP/MED1
Positive_regulation (requires) of Gene_expression (signaling) of MED1
1) Confidence 0.35 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.38 Pain Relevance 0
signaling requires PBP/MED1
Positive_regulation (requires) of Gene_expression (signaling) of PBP
2) Confidence 0.35 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.38 Pain Relevance 0
This is surprising since NCoA6(ASC-2), TRAP220 and all the p160 coactivators are thought to use the same interaction surface of liganded-RAR.
Positive_regulation (since) of Gene_expression (surprising) of TRAP220
3) Confidence 0.19 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0

General Comments

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