INT225439

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 9.81
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (Sae1) nucleus (Sae1) cellular_component (Sae1)
ligase activity (Sae1)
Anatomy Link Frequency
E1a 5
Sae1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 104 99.16 Very High Very High Very High
Inflammation 48 6.00 Low Low
Potency 15 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 336 99.90 Very High Very High Very High
Infection 150 99.60 Very High Very High Very High
Cancer 590 94.96 High High
Disease 27 81.28 Quite High
Melanoma 75 78.80 Quite High
Malignant Neoplastic Disease 17 78.64 Quite High
Metastasis 58 71.72 Quite High
Pancreatic Cancer 2 61.68 Quite High
Apoptosis 178 60.68 Quite High
Toxicity 31 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Classic studies suggest that highly variable E1A levels allow effective replication without direct correlation between E1A expression and virion production [48].
Gene_expression (expression) of E1A
1) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.64 Pain Relevance 0.11
Thus, is it quite possible, that even though E1A expression was affected due to dexamethasone inhibiting the promoters, the effect was not dramatic enough to be seen as a difference in tumor growth curves.
Gene_expression (expression) of E1A associated with cancer and dexamethasone
2) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.68 Pain Relevance 0.09
However, ligand-dependent activation of NRs by NCoA6(NRC) was completely blocked by expression of E1A, which is known to inactivate CBP/p300 [Mahajan and Samuels, 2000].
Gene_expression (expression) of E1A
3) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The expressions of E1a and Apoptin were analyzed by Western blot as described previously [45].
Spec (analyzed) Gene_expression (expressions) of E1a in E1a
4) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.51 Pain Relevance 0
Infection of HEM with Ad-CMV-E1a-Apoptin or Ad-CMV-E1a resulted in E1a production, whereas infection with Ad-hTERT-E1a-Apoptin, Ad-hTERT-E1a, Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock resulted in barely detectable E1a expression (Figure 1D).
Gene_expression (expression) of E1a in E1a associated with cytomegalovirus infection and infection
5) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.08 Pain Relevance 0
A375 or B16 cells infected with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a produced E1a proteins (36 kDa); however, cells infected with Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock did not (Figure 1B and 1C).
Gene_expression (produced) of E1a in E1a associated with cytomegalovirus infection
6) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.11 Pain Relevance 0
Infection of HEM with Ad-CMV-E1a-Apoptin or Ad-CMV-E1a resulted in E1a production, whereas infection with Ad-hTERT-E1a-Apoptin, Ad-hTERT-E1a, Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock resulted in barely detectable E1a expression (Figure 1D).
Gene_expression (production) of E1a in E1a associated with cytomegalovirus infection and infection
7) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.16 Pain Relevance 0
We generated two additional control replicating adenoviruses without Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a, in which E1a is expressed by the hTERT or CMV promoters, respectively.
Gene_expression (expressed) of E1a in E1a associated with cytomegalovirus infection
8) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.63 Pain Relevance 0

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