INT225462

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
neurons 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 12 100.00 Very High Very High Very High
cINOD 1 54.72 Quite High
Inflammation 59 54.16 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 100.00 Very High Very High Very High
Amyloid Plaque 1 90.88 High High
Toxicity 1 88.48 High High
Neurodegenerative Disease 17 87.68 High High
Alzheimer's Dementia 4 86.48 High High
Disease 76 77.52 Quite High
Brain Disease 1 77.04 Quite High
Cognitive Disorder 25 74.28 Quite High
Drug Induced Neurotoxicity 1 73.36 Quite High
Neuroblastoma 1 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, further APP fragments were discovered and TDP-43 as well as ?
Positive_regulation (discovered) of Positive_regulation (fragments) of APP
1) Confidence 0.44 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.59 Pain Relevance 0
On neurons, Abeta activation of RAGE will generate oxidative stress and activate NF-KB.
Positive_regulation (activate) of Positive_regulation (activation) of Abeta in neurons associated with stress and abeta
2) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.77 Pain Relevance 0.55
The STL region is inhibitory in the context of full length NCoA6(NRC) and its deletion enhances the intrinsic activation potential of AD1 and AD2 in NCoA6(NRC) [Mahajan and Samuels, 2000].
Positive_regulation (enhances) of Positive_regulation (activation) of AD1
3) Confidence 0.05 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0

General Comments

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