INT22547

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 23
Total Number 29
Disease Relevance 8.04
Pain Relevance 16.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
nucleus accumbens 2
medial 2
apoptotic cell 2
ventral 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 101 100.00 Very High Very High Very High
Nucleus accumbens 94 100.00 Very High Very High Very High
Ventral tegmentum 16 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
nMDA receptor antagonist 15 100.00 Very High Very High Very High
lidocaine 13 100.00 Very High Very High Very High
Kappa opioid receptor 3 99.92 Very High Very High Very High
Glutamate 581 99.90 Very High Very High Very High
Eae 24 99.84 Very High Very High Very High
gABA 14 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 426 100.00 Very High Very High Very High
Status Epilepticus 58 99.72 Very High Very High Very High
Death 298 99.04 Very High Very High Very High
Opiate Addiction 2 96.84 Very High Very High Very High
Drug Induced Neurotoxicity 7 94.56 High High
Recurrence 7 90.28 High High
Drug Dependence 2 88.00 High High
Pancreatitis 39 86.72 High High
Targeted Disruption 5 86.72 High High
Adhesions 2 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, it is suggested as a useful method to study effects of anti-craving-drugs on CPP expression, thereby reducing the overall number of experimental animals.
Regulation (effects) of Gene_expression (expression) of CPP
1) Confidence 0.62 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.60
However, microinjection of beta-funaltrexamine into the medial thalamus after morphine conditioning trials, but 23 h prior to a test session, had no effect on the expression of CPP.
Neg (no) Regulation (effect) of Gene_expression (expression) of CPP in medial associated with thalamus and morphine
2) Confidence 0.60 Published 2008 Journal Neuroscience Section Abstract Doc Link 18222040 Disease Relevance 0 Pain Relevance 1.14
The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.
Regulation (modulating) of Gene_expression (expression) of CPP associated with kappa opioid receptor and morphine
3) Confidence 0.59 Published 2006 Journal Peptides Section Title Doc Link 17097192 Disease Relevance 0.10 Pain Relevance 1.29
After conditioning, CPP expression and locomotion were determined simultaneously in the presence and absence of the respective reward (i.e. food or drug), or after application of 50 mg/kg MPEP (the dose that was most effective in reducing morphine CPP expression in our previous study).
Regulation (effective) of Gene_expression (expression) of CPP associated with morphine
4) Confidence 0.39 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.29
Our studies show that up-regulation of caspase-3 expression preceded neuronal cell death, supporting the possibility that glutamate-induced apoptotic cell death was the consequence of up-regulation of caspase-3 gene in cortical neurons.
Regulation (regulation) of Gene_expression (expression) of caspase-3 in apoptotic cell associated with glutamate, apoptosis and death
5) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 1.01 Pain Relevance 0.22
Since we observed that glutamate-induced cell death was effectively blocked by both caspase-3 specific inhibitor z-DEVD and pan-caspase-inhibitor z-VAD, these data further provide evidence that caspase-3 protease is not only up-regulated, but is also activated during glutamate-induced cell death.
Regulation (regulated) of Gene_expression (protease) of caspase-3 associated with glutamate and death
6) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.62 Pain Relevance 0.18
Effects of glutamate and estrogens on caspase-3 protein levels
Regulation (estrogens) of Gene_expression (levels) of caspase-3 associated with glutamate
7) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.49 Pain Relevance 0.38
The effects of lidocaine and bupivacaine on protein expression of cleaved caspase 3 and tyrosine phosphorylation in the rat hippocampal slice.
Regulation (effects) of Gene_expression (expression) of caspase 3 associated with lidocaine
8) Confidence 0.34 Published 2007 Journal Anesth. Analg. Section Title Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.71
Caspase-3 protein expression in the treated group was significantly greater
Regulation (greater) of Gene_expression (expression) of Caspase-3
9) Confidence 0.29 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.44 Pain Relevance 0.15
The present study was performed to examine the effect of 100 Hz peripheral electric stimulation (PES) on the expression of morphine-induced CPP.
Spec (examine) Regulation (effect) of Spec (examine) Gene_expression (expression) of CPP associated with morphine
10) Confidence 0.26 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885422 Disease Relevance 0 Pain Relevance 0.71
Visualization of mitochondrial cytochrome-c release and caspase-3 expression
Regulation (Visualization) of Gene_expression (expression) of caspase-3
11) Confidence 0.26 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0 Pain Relevance 0
Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity.
Neg (no) Regulation (effect) of Gene_expression (expression) of CPP associated with eae and morphine
12) Confidence 0.24 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.21 Pain Relevance 0.95
To examine the effect of aripiprazole on the expression of morphine-induced CPP, rats received aripiprazole (0, 0.03, 0.1,and 0.3 mg/kg, i.p.) 30 min before testing for the expression of CPP.
Spec (examine) Regulation (effect) of Spec (examine) Gene_expression (expression) of CPP associated with morphine
13) Confidence 0.24 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.18 Pain Relevance 0.76
Furthermore, only expression of amphetamine CPP was inhibited by MPEP, while expression of food and MDMA CPP was not affected, suggesting that the MPEP-induced inhibition of amphetamine CPP expression was not causally linked to the reduction of locomotion.
Neg (not) Regulation (affected) of Gene_expression (expression) of CPP
14) Confidence 0.24 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.26
The present study examined the effects of naloxone on acquisition and expression of morphine-induced conditioned place preference (CPP).
Spec (examined) Regulation (effects) of Gene_expression (expression) of CPP associated with narcan and morphine
15) Confidence 0.24 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2305008 Disease Relevance 0 Pain Relevance 0.62
It is concluded that GABA(A) and GABA(B) receptor subtypes within the ventral tegmental area may have different effects on the expression of morphine-induced CPP.
Regulation (effects) of Gene_expression (expression) of CPP in ventral associated with ventral tegmentum, gaba and morphine
16) Confidence 0.23 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.46
In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in rats.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CPP associated with ventral tegmentum and morphine
17) Confidence 0.22 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19073220 Disease Relevance 0 Pain Relevance 0.93
Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 microl per side) dose-dependently reduced the acquisition and expression of morphine-induced CPP in morphine-sensitized rats, while bilateral intra-accumbal administration of neither saline nor DMSO (0.5 microl/side) had effects on the acquisition and expression of morphine-induced CPP in sensitized rats.
Regulation (effects) of Gene_expression (expression) of CPP associated with morphine
18) Confidence 0.21 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18773925 Disease Relevance 0 Pain Relevance 1.57
The results indicated that CB1 receptors within the nucleus accumbens are involved in the acquisition and expression of morphine-induced CPP in sensitized rats.
Regulation (involved) of Gene_expression (expression) of CPP in nucleus accumbens associated with nucleus accumbens and morphine
19) Confidence 0.21 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18773925 Disease Relevance 0 Pain Relevance 1.53
The contribution of non-apoptotic mechanisms in the CA1 region after SE is also corroborated by our recent finding that the expression of Bax and caspase-3 proteins remained unchanged after SE in P21 rats [23].
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of caspase-3 associated with status epilepticus and apoptosis
20) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.88 Pain Relevance 0.06

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