INT22549

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Context Info
Confidence 0.56
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 48
Total Number 49
Disease Relevance 29.50
Pain Relevance 23.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
striatum 4
apoptotic cell 4
hepatocytes 4
poly 4
neurons 4
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 114 100.00 Very High Very High Very High
anesthesia 19 100.00 Very High Very High Very High
cocaine 15 100.00 Very High Very High Very High
Nucleus accumbens 62 99.90 Very High Very High Very High
qutenza 15 99.90 Very High Very High Very High
Dopamine 114 99.88 Very High Very High Very High
Glutamate 436 99.84 Very High Very High Very High
Hippocampus 29 99.74 Very High Very High Very High
Enkephalin 9 99.56 Very High Very High Very High
narcan 15 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 617 100.00 Very High Very High Very High
Ocular Hypertension 225 100.00 Very High Very High Very High
Diabetes Mellitus 86 100.00 Very High Very High Very High
Hypoxia 26 100.00 Very High Very High Very High
Ulcers 9 100.00 Very High Very High Very High
Death 386 99.98 Very High Very High Very High
Stress 98 99.76 Very High Very High Very High
Injury 84 99.64 Very High Very High Very High
Stomach Cancer 5 99.64 Very High Very High Very High
Necrosis 29 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-induced CPP was also significantly increased in the animals that had previously received the 3-days intra-NAc injections of SKF 38393 (4 and 8 microg/rat) or quinpirole (2 and 4 microg/rat, intra-NAc).
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.56 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16472879 Disease Relevance 0 Pain Relevance 0.79
Results showed that early exposure to methylphenidate (5 mg/kg) increased the magnitude of morphine-induced CPP.
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
2) Confidence 0.51 Published 2007 Journal Brain Res. Section Abstract Doc Link 17274963 Disease Relevance 0.11 Pain Relevance 0.40
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Positive_regulation (anesthesia-induced) of Positive_regulation (activation) of caspase-3 associated with anesthesia and apoptosis
3) Confidence 0.47 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.62 Pain Relevance 0.66
Muscimol (25 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
4) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.48
Bicuculline (10 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.57
We found that activated caspase-3, its actin cleavage product fractin, and components of the apoptosome were increased significantly in DA-depleted striatum.
Positive_regulation (increased) of Positive_regulation (activated) of caspase-3 in striatum associated with dopamine
6) Confidence 0.42 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16180225 Disease Relevance 0.49 Pain Relevance 0.53
Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systems.
Positive_regulation (enhances) of Positive_regulation (activated) of caspase-3 associated with dopamine and enkephalin
7) Confidence 0.42 Published 2005 Journal J. Neurosci. Res. Section Title Doc Link 16180225 Disease Relevance 0.45 Pain Relevance 0.51
These findings indicate that naloxone blocks the acquisition, but enhances the expression of morphine-induced CPP.
Positive_regulation (enhances) of Positive_regulation (induced) of CPP associated with narcan and morphine
8) Confidence 0.41 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2305008 Disease Relevance 0 Pain Relevance 1.46
Malondialdehyde levels and caspase-3 activation in ulcers were increased by indomethacin (+79% and +3.7 folds vs control ulcer, respectively), and these effects were counteracted by pantoprazole (-77.9% and -3.5 folds vs indomethacin, respectively), but not famotidine.
Positive_regulation (increased) of Positive_regulation (activation) of caspase-3 associated with ulcers
9) Confidence 0.38 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18853145 Disease Relevance 0.95 Pain Relevance 0.13
Our studies show that up-regulation of caspase-3 expression preceded neuronal cell death, supporting the possibility that glutamate-induced apoptotic cell death was the consequence of up-regulation of caspase-3 gene in cortical neurons.
Positive_regulation (regulation) of Positive_regulation (up) of caspase-3 in apoptotic cell associated with glutamate, apoptosis and death
10) Confidence 0.37 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.98 Pain Relevance 0.21
Our studies show that up-regulation of caspase-3 expression preceded neuronal cell death, supporting the possibility that glutamate-induced apoptotic cell death was the consequence of up-regulation of caspase-3 gene in cortical neurons.
Positive_regulation (up) of Positive_regulation (regulation) of caspase-3 in apoptotic cell associated with glutamate, apoptosis and death
11) Confidence 0.37 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.98 Pain Relevance 0.21
Intra-medial septum injections of L-arginine but not L-NAME or sulpiride, 1-2 min before testing, increased the expression of morphine-induced CPP.
Positive_regulation (increased) of Positive_regulation (induced) of CPP in medial associated with morphine
12) Confidence 0.36 Published 2003 Journal Brain Res. Section Abstract Doc Link 12763619 Disease Relevance 0 Pain Relevance 0.78
E2 reversed caspase-3 activation induced by OBX (0.37 ± 0.004 OD arbitrary units/mg protein in OBX group vs 0.25 ± 0.004 OD arbitrary units/mg protein in an OBX+17?
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3
13) Confidence 0.35 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.35 Pain Relevance 0.04
Recently, Szymczyk et al. (21) reported that sodium arsenite (NaAsO2, As) triggered the production of H2O2 and induced apoptosis via the activation of caspase-3, which is dependent on the production of H2O2 in preosteoclastic cells.
Positive_regulation (dependent) of Positive_regulation (activation) of caspase-3 associated with apoptosis
14) Confidence 0.33 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2396482 Disease Relevance 1.24 Pain Relevance 0.06
On the other hand, the CPP induced by morphine (5mg/kg, s.c.) was significantly increased in the animals that had previously received the 3-days sulpiride administration (5 microg/rat, intra-NAc).
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
15) Confidence 0.33 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16472879 Disease Relevance 0 Pain Relevance 0.88
RESULTS: In outbred rats, DMCM/restraint increased both HPA activity and morphine-induced CPP, while antalarmin decreased CPP and produced a slight, but nonsignificant, decrease in corticosterone levels.
Positive_regulation (increased) of Positive_regulation (induced) of CPP
16) Confidence 0.32 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016707 Disease Relevance 0.07 Pain Relevance 0
The extrinsic apoptotic pathway was induced by over-expression of tumor necrosis factor (TNF) which led to the activation of caspase-3 in both examined structures.
Spec (examined) Positive_regulation (led) of Spec (examined) Positive_regulation (activation) of caspase-3 associated with necrosis, cancer and apoptosis
17) Confidence 0.28 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19150648 Disease Relevance 0.53 Pain Relevance 0.29
Pre-exposure of hepatocytes to a JNK inhibitor SP600125 prevented As-induced caspase-3 activation, ROS production and loss in cell viability.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in hepatocytes
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.99 Pain Relevance 0
The maintenance of morphine CPP could be induced by repeated footshock and this effect was significantly attenuated by pretreatment of 10 microg alpha-helical CRF (i.c.v.) and 10 mg CP-154,526 (i.p.).
Positive_regulation (induced) of Positive_regulation (maintenance) of morphine CPP associated with morphine
19) Confidence 0.26 Published 2000 Journal Neuroreport Section Abstract Doc Link 10943688 Disease Relevance 0.37 Pain Relevance 0.83
Early activation of caspases involved in the mitochondrial apoptotic pathway was observed, culminating in caspase 3 activation, Poly-ADP Ribose Polymerase (PARP) cleavage and DNA fragmentation.
Positive_regulation (culminating) of Positive_regulation (activation) of caspase 3 in cleavage associated with apoptosis
20) Confidence 0.24 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17250679 Disease Relevance 0.67 Pain Relevance 0.17

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