INT225515

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncoa6, Rbm39) mRNA processing (Rbm39) RNA binding (Rbm39)
enzyme binding (Ncoa6) protein complex (Ncoa6)
Ncoa6 (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 7.72 Low Low
Paracetamol 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 72 76.40 Quite High
Wound Healing 60 73.44 Quite High
Adhesions 8 50.08 Quite High
Targeted Disruption 96 5.00 Very Low Very Low Very Low
Breast Cancer 32 5.00 Very Low Very Low Very Low
Cancer 28 5.00 Very Low Very Low Very Low
Obesity 20 5.00 Very Low Very Low Very Low
Repression 16 5.00 Very Low Very Low Very Low
Shock 12 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCoA6 has been shown to interact with a number of factors in vitro and in vivo including CBP/p300, DNA-PKc, DRIP130, NIF-1, CAPER, CoAA and PIMT.
NCoA6 Binding (interact) of CAPER
1) Confidence 0.14 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.26 Pain Relevance 0
CAPER contains three RRMs and associates with c-Jun and the ligand-bound ER-LBD region via RRM3, while the C-terminus of CAPER was shown to bind NCoA6(ASC-2) [Jung et al., 2002].
NCoA6 Binding (bind) of CAPER
2) Confidence 0.14 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CAPER, PIMT and CoAA were identified in yeast two-hybrid screens to interact with NCoA6 (Figure 2).
NCoA6 Binding (interact) of CAPER
3) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The basis for ER specificity was not clarified, but the specificity implies that CAPER may not enhance ER function through association with NCoA6(ASC-2), which interacts with and enhances activation of NRs including RARs, RXRs, TR and GR.
NCoA6 Binding (association) of CAPER
4) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox