INT225516

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncoa6) enzyme binding (Ncoa6) protein complex (Ncoa6)
Ncoa6 (Mus musculus)
D0Nrs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 126 82.56 Quite High
Wound Healing 105 81.44 Quite High
Herpes Simplex Virus 7 68.96 Quite High
Shock 21 16.08 Low Low
Retinoblastoma 7 11.96 Low Low
Targeted Disruption 168 5.00 Very Low Very Low Very Low
Breast Cancer 56 5.00 Very Low Very Low Very Low
Cancer 49 5.00 Very Low Very Low Very Low
Obesity 35 5.00 Very Low Very Low Very Low
Repression 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the AD2 domain was found to be essential for NR signaling and AF2-dependent enhancement of NRs by NCoA6(NRC) [Mahajan et al., 2007].
NCoA6 Positive_regulation (enhancement) of NRs
1) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.07 Pain Relevance 0
Interestingly, the AD2 domain was found to be essential for NR signaling and AF2-dependent enhancement of NRs by NCoA6(NRC) [Mahajan et al., 2007].
NRC Positive_regulation (enhancement) of NRs
2) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.07 Pain Relevance 0
However, ligand-dependent activation of NRs by NCoA6(NRC) was completely blocked by expression of E1A, which is known to inactivate CBP/p300 [Mahajan and Samuels, 2000].
NRC Positive_regulation (activation) of NRs
3) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
However, ligand-dependent activation of NRs by NCoA6(NRC) was completely blocked by expression of E1A, which is known to inactivate CBP/p300 [Mahajan and Samuels, 2000].
NCoA6 Positive_regulation (activation) of NRs
4) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
It is unclear whether NCoA6 acts only through these complexes to activate NRs and other transcription factors such as c-Fos, c-Jun, CREB and NF-kB.
NCoA6 Spec (whether) Positive_regulation (activate) of NRs
5) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Whether association of NCoA6 with CBP/p300 is essential for ligand-dependent activation by NRs or other transcription factors activated by NCoA6 has not been directly addressed using CBP-/- cells.
NCoA6 Positive_regulation (activated) of NRs
6) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Whether DRIP130 and NCoA6 synergistically activate NRs and/or other transcription factors has not been explored.


NCoA6 Spec (Whether) Positive_regulation (activate) of NRs
7) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox