INT225542

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

D0Nrs1 (Mus musculus)
Asc2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 72 93.92 High High
Congenital Anomalies 3 82.96 Quite High
Microphthalmia 3 71.44 Quite High
Cataract 3 67.84 Quite High
Repression 12 46.08 Quite Low
Wound Healing 45 17.04 Low Low
Apoptosis 54 16.32 Low Low
Herpes Simplex Virus 3 5.32 Low Low
Breast Cancer 24 5.00 Very Low Very Low Very Low
Cancer 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCoA6(ASC-2) associates with the majority of the NRs through LxxLL-1, while LxxLL-2 specifically associates with LXRs.
NRs Binding (associates) of ASC-2
1) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.63 Pain Relevance 0
Barring one initial report with NCoA6(ASC-2), which suggested that NRs interact through a region of NCoA6(ASC-2) (amino acids 586-860) that did not contain any LxxLL motif [Lee et al., 1999], all other studies confirmed that of the two LxxLL motifs in NCoA6, LxxLL-1 is necessary for interaction with a wide spectrum of NRs including TRs, RXRs, RARs, GR, ERs, VDR and the PPARs [Caira et al., 2000; Ko et al., 2000; Mahajan and Samuels, 2000].
NRs Binding (interact) of ASC-2
2) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Barring one initial report with NCoA6(ASC-2), which suggested that NRs interact through a region of NCoA6(ASC-2) (amino acids 586-860) that did not contain any LxxLL motif [Lee et al., 1999], all other studies confirmed that of the two LxxLL motifs in NCoA6, LxxLL-1 is necessary for interaction with a wide spectrum of NRs including TRs, RXRs, RARs, GR, ERs, VDR and the PPARs [Caira et al., 2000; Ko et al., 2000; Mahajan and Samuels, 2000].
NRs Binding (interact) of ASC-2
3) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

General Comments

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