INT225552

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.04
Pain Relevance 0

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nucleus (Ncoa6) enzyme binding (Ncoa6) protein complex (Ncoa6)
nr (Mus musculus)
Ncoa6 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 192 91.20 High High
Embryonic Lethality 16 85.72 High High
Wound Healing 120 83.00 Quite High
Apoptosis 144 82.40 Quite High
Repression 32 70.64 Quite High
Cataract 8 59.68 Quite High
Microphthalmia 8 58.12 Quite High
Congenital Anomalies 8 52.32 Quite High
Breast Cancer 64 5.00 Very Low Very Low Very Low
Cancer 56 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(L398R), or deletion of helix 12, abolish the association of the NR with NCoA6(NRC) in vitro and in vivo [Mahajan and Samuels, 2000].
NR Binding (association) of NRC
1) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
(L398R), or deletion of helix 12, abolish the association of the NR with NCoA6(NRC) in vitro and in vivo [Mahajan and Samuels, 2000].
NR Binding (association) of NCoA6
2) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, the phenotypes may result not just from inhibition of NCoA6(ASC-2)-NR interaction, but also from inactivation of a number of receptors that bind DN1 in vivo.
NR Binding (interaction) of NCoA6
3) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.78 Pain Relevance 0
Embedded in this region is the LxxLL-1 motif, which is involved in NR interaction, but not homodimerization of NCoA6(NRC), as suggested by mutational analysis and dimerization data.
NR Neg (not) Binding (interaction) of NCoA6
4) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
NCoA6 may emerge as a specific coactivator for a specific set of NRs due to the fact that NCoA6 displays NR-specific interaction through LxxLL-2.
NR Binding (interaction) of NCoA6
5) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.25 Pain Relevance 0
Embedded in this region is the LxxLL-1 motif, which is involved in NR interaction, but not homodimerization of NCoA6(NRC), as suggested by mutational analysis and dimerization data.
NR Neg (not) Binding (interaction) of NRC
6) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, yeast two-hybrid assays were used to provide evidence that association with ligand-bound NR leads to a change in NCoA6(NRC) which exposes its activation domains.
NR Binding (bound) of NRC
7) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, yeast two-hybrid assays were used to provide evidence that association with ligand-bound NR leads to a change in NCoA6(NRC) which exposes its activation domains.
NR Binding (bound) of NCoA6
8) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

General Comments

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