INT225556

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 2
Speculated 5
Reported most in Body
Documents 1
Total Number 27
Disease Relevance 1.70
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cytip) nucleus (Ncoa6) enzyme binding (Ncoa6)
protein complex (Ncoa6) cytoplasm (Cytip)
Ncoa6 (Mus musculus)
Cytip (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 27 79.88 Quite High
Paracetamol 54 6.76 Low Low
Inflammation 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 81 82.64 Quite High
Apoptosis 486 82.16 Quite High
Lung Cancer 27 78.56 Quite High
Wound Healing 405 77.92 Quite High
Cardiovascular Disease 27 76.72 Quite High
Obesity 135 74.72 Quite High
Targeted Disruption 648 73.84 Quite High
Insulin Resistance 54 73.76 Quite High
Adhesions 54 63.44 Quite High
Cancer 189 62.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of NCoA6(NRC) with CBP involves the C-terminal region of NCoA6(NRC), which includes AD2.
NCoA6 Binding (Association) of CBP
1) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0
Association of NCoA6(NRC) with CBP involves the C-terminal region of NCoA6(NRC), which includes AD2.
NRC Binding (Association) of CBP
2) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0
This suggests that the association of NCoA6(NRC) with CBP in mammalian cells may be mediated through another factor.
NCoA6 Binding (association) of CBP
3) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Although NCoA6(NRC) associates with CBP in mammalian cells, no direct association between full length NCoA6(NRC) and full length CBP was identified in yeast [Tian et al., 2006].
NRC Binding (associates) of CBP
4) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Although NCoA6(NRC) associates with CBP in mammalian cells, no direct association between full length NCoA6(NRC) and full length CBP was identified in yeast [Tian et al., 2006].
NCoA6 Binding (associates) of CBP
5) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In contrast with these findings, another study reported that NCoA6(ASC-2) associated with various regions of CBP in yeast and by in vitro binding, although full length CBP was not examined [Lee et al., 2001].
NCoA6 Spec (examined) Binding (associated) of CBP
6) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
This suggests that the association of NCoA6(NRC) with CBP in mammalian cells may be mediated through another factor.
NRC Binding (association) of CBP
7) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Consistent with this notion is the finding that NCoA6(NRC) forms a high affinity complex with CBP (Figure 2) in vivo [Mahajan and Samuels, 2000].
NRC Binding (complex) of CBP
8) Confidence 0.10 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.07 Pain Relevance 0
Consistent with this notion is the finding that NCoA6(NRC) forms a high affinity complex with CBP (Figure 2) in vivo [Mahajan and Samuels, 2000].
NCoA6 Binding (complex) of CBP
9) Confidence 0.10 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.07 Pain Relevance 0
Association of NCoA6(NRC) with CBP involves the C-terminal region of NCoA6(NRC), which includes AD2.
NRC Binding (Association) of CBP
10) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0
The potential role of NCoA6 as a co-integrator is suggested by its ability to enhance transcriptional activation of a wide variety of transcription factors and from its in vivo association with a number of known cofactors including CBP/p300.
NCoA6 Binding (association) of CBP
11) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2254332 Disease Relevance 0.15 Pain Relevance 0
NCoA6 has been shown to interact with a number of factors in vitro and in vivo including CBP/p300, DNA-PKc, DRIP130, NIF-1, CAPER, CoAA and PIMT.
NCoA6 Binding (interact) of CBP
12) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.26 Pain Relevance 0
Expression of NCoA6(NRC) in 293 cells followed by extraction, affinity adsorption and Western blotting indicated that a significant amount of CBP in the cell is associated with NCoA6(NRC).
NCoA6 Binding (associated) of CBP
13) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0
In this regard, many of the factors described above have been shown to interact with CBP/p300, suggesting that NCoA6 may function to enhance the activity of such factors through its interaction with CBP/p300, which occurs in vivo.
NCoA6 Binding (interaction) of CBP
14) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.21 Pain Relevance 0.04
Thus, these studies raise the possibility that NCoA6, through its associations, and much like CBP, may be a co-integrator regulating transcription and cell signaling.
NCoA6 Binding (associations) of CBP
15) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.30 Pain Relevance 0
In contrast with these findings, another study reported that NCoA6(ASC-2) associated with various regions of CBP in yeast and by in vitro binding, although full length CBP was not examined [Lee et al., 2001].
NCoA6 Spec (examined) Binding (associated) of CBP
16) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
p300 could not be detected in the same Western blot, suggesting that NCoA6(NRC) might preferentially associate with CBP in vivo [Mahajan and Samuels, 2000].
NRC Spec (might) Binding (associate) of CBP
17) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.05 Pain Relevance 0
Thus, like CBP, NCoA6 may act as a transcriptional co-integrator through its interaction with a variety of transcription factors, including the NRs.
NCoA6 Binding (interaction) of CBP
18) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.20 Pain Relevance 0
In contrast with these findings, another study reported that NCoA6(ASC-2) associated with various regions of CBP in yeast and by in vitro binding, although full length CBP was not examined [Lee et al., 2001].
NCoA6 Spec (examined) Binding (associated) of CBP
19) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NRC Binding (association) of CBP
20) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

General Comments

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