INT22556

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.25
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL3A1) extracellular region (COL3A1)
Anatomy Link Frequency
fascia 3
bursa 2
fibroblast 2
dermis 1
COL3A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 8 98.56 Very High Very High Very High
Pain 5 98.02 Very High Very High Very High
Inflammation 9 96.36 Very High Very High Very High
cytokine 4 93.80 High High
antagonist 1 90.16 High High
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 4 99.56 Very High Very High Very High
Eosinophilia 4 99.02 Very High Very High Very High
Fasciitis 4 98.66 Very High Very High Very High
Fibrosis 4 98.56 Very High Very High Very High
Systemic Sclerosis 8 97.76 Very High Very High Very High
INFLAMMATION 9 96.36 Very High Very High Very High
Syndrome 7 94.60 High High
Sleep Disorders 4 92.88 High High
Tinnitus 4 92.40 High High
Disease 3 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased hybridization signals were detected in the deep dermis and fascia, indicating enhanced expression of the collagen gene.
Positive_regulation (enhanced) of Gene_expression (expression) of collagen gene in fascia
1) Confidence 0.37 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.86 Pain Relevance 0.08
Development of diffuse fasciitis with eosinophilia during L-tryptophan treatment: demonstration of elevated type I collagen gene expression in affected tissues.
Positive_regulation (elevated) of Gene_expression (expression) of collagen gene associated with pain, fasciitis and eosinophilia
2) Confidence 0.32 Published 1990 Journal Ann. Intern. Med. Section Title Doc Link 2306063 Disease Relevance 0.98 Pain Relevance 0.17
The temporal association of L-tryptophan use and the development of a scleroderma-like illness in these four patients suggests a causal relation between L-tryptophan or its metabolites and the stimulation of fibroblast collagen gene expression that results in dermal and fascial fibrosis.
Positive_regulation (stimulation) of Gene_expression (expression) of collagen gene in fibroblast associated with fibrosis and systemic sclerosis
3) Confidence 0.25 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.89 Pain Relevance 0.09
Increased hybridization signals were detected in the deep dermis and fascia, indicating enhanced expression of the collagen gene.
Positive_regulation (enhanced) of in dermis Gene_expression (expression) of collagen gene in fascia
4) Confidence 0.13 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.86 Pain Relevance 0.08
In bursa samples from patients with ruptures of the rotator cuff, expression of collagen types I and III was enhanced compared with normal controls [16].
Positive_regulation (enhanced) of Gene_expression (expression) of collagen types I and III in bursa associated with rupture
5) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.66 Pain Relevance 0.22

General Comments

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