INT225569

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.63
Pain Relevance 0.04

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nucleus (Ncoa6, Ep300) transferase activity, transferring acyl groups (Ep300) DNA binding (Ep300)
enzyme binding (Ncoa6) transcription factor binding (Ep300) protein complex (Ncoa6)
Ncoa6 (Mus musculus)
Ep300 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 79.88 Quite High
Paracetamol 14 6.76 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 126 82.16 Quite High
Lung Cancer 7 78.56 Quite High
Targeted Disruption 168 74.24 Quite High
Wound Healing 105 73.44 Quite High
Adhesions 14 63.84 Quite High
Shock 21 62.24 Quite High
Necrosis 7 7.76 Low Low
Breast Cancer 56 5.00 Very Low Very Low Very Low
Cancer 49 5.00 Very Low Very Low Very Low
Obesity 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other in vitro binding studies indicated that the C-terminal region of p300 (amino acids 1661-2414) can associate with the C-terminal region of NCoA6(TRBP) [Ko et al., 2000].
NCoA6 Binding (associate) of p300
1) Confidence 0.18 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
NCoA6 has been shown to interact with a number of factors in vitro and in vivo including CBP/p300, DNA-PKc, DRIP130, NIF-1, CAPER, CoAA and PIMT.
NCoA6 Binding (interact) of p300
2) Confidence 0.14 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.26 Pain Relevance 0
The potential role of NCoA6 as a co-integrator is suggested by its ability to enhance transcriptional activation of a wide variety of transcription factors and from its in vivo association with a number of known cofactors including CBP/p300.
NCoA6 Binding (association) of p300
3) Confidence 0.14 Published 2008 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2254332 Disease Relevance 0.15 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NRC Binding (association) of p300
4) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Whether association of NCoA6 with CBP/p300 is essential for ligand-dependent activation by NRs or other transcription factors activated by NCoA6 has not been directly addressed using CBP-/- cells.
NCoA6 Spec (Whether) Binding (association) of p300
5) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NCoA6 Binding (association) of p300
6) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In this regard, many of the factors described above have been shown to interact with CBP/p300, suggesting that NCoA6 may function to enhance the activity of such factors through its interaction with CBP/p300, which occurs in vivo.
NCoA6 Binding (interaction) of p300
7) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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