INT22557

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 17
Disease Relevance 20.18
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (BMP1) peptidase activity (BMP1) extracellular space (BMP1)
small molecule metabolic process (BMP1) extracellular region (BMP1) lipid metabolic process (BMP1)
Anatomy Link Frequency
adipose tissue 3
urine 3
eyes 2
skin 1
saliva 1
BMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 126 99.26 Very High Very High Very High
Dextromethorphan 14 98.64 Very High Very High Very High
antagonist 20 98.54 Very High Very High Very High
anesthesia 71 97.68 Very High Very High Very High
fibrosis 3 97.20 Very High Very High Very High
analgesia 42 97.04 Very High Very High Very High
Analgesic 14 92.84 High High
Glutamate 42 91.04 High High
withdrawal 14 89.52 High High
nMDA receptor 42 89.36 High High
Disease Link Frequency Relevance Heat
Poisoning 294 100.00 Very High Very High Very High
Schizophrenia 74 100.00 Very High Very High Very High
Sleep Disorders 99 99.80 Very High Very High Very High
Coma 28 99.64 Very High Very High Very High
Obesity 14 99.36 Very High Very High Very High
Respiratory Failure 28 99.26 Very High Very High Very High
Nystagmus 56 99.20 Very High Very High Very High
Depression 70 99.16 Very High Very High Very High
Heart Rate Under Development 98 98.76 Very High Very High Very High
Pressure And Volume Under Development 143 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical picture may wax and wane between extreme agitation and sedation, because PCP can produce CNS stimulation and depression through its different clinical effects in the CNS.
Gene_expression (produce) of PCP associated with depression and sleep disorders
1) Confidence 0.59 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.90 Pain Relevance 0.81
Therefore, a qualitative urine toxicologic screen has become mandatory standard of care for any patient, infant or adult, with altered mental status of unknown etiology.13 Although earlier literature describes three dose-related stages of PCP intoxication, quantitative PCP levels do not correlate well with clinical findings and thus should not guide clinical management.1, 6, 13, 20, 22
Gene_expression (levels) of PCP in urine associated with poisoning
2) Confidence 0.59 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.74 Pain Relevance 0.12
In animal experiments PCP-binding antibodies actually increased serum concentrations of PCP, indicating that they simply alter its distribution.16 PCP levels are highest in adipose tissue, and because of its slow, uneven release from lipid stores, the half-life of PCP is believed to be three days.3, 13 Due to the brain’s high lipid content and ion trapping, cerebral levels of PCP may be nine times serum levels, allowing its CNS effects to last from seven hours to as long as seven days in chronic users.17
Gene_expression (antibodies) of PCP-binding in adipose tissue associated with obesity
3) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.33 Pain Relevance 0.11
Effects of PCP in Children
Gene_expression (Effects) of PCP
4) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.51 Pain Relevance 0.30
Patients recovering from PCP exposure may undergo an emergence reaction as the drug is eliminated, consisting of psychosis, bizarre behavior, or depression that may last from days to weeks.28 Prolonged psychosis is more commonly seen in chronic abusers, and is a poor prognostic sign, as the patient may go on to develop true schizophrenia.
Gene_expression (exposure) of PCP associated with depression, psychosis and schizophrenia
5) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.98 Pain Relevance 0.25
In animal experiments PCP-binding antibodies actually increased serum concentrations of PCP, indicating that they simply alter its distribution.16 PCP levels are highest in adipose tissue, and because of its slow, uneven release from lipid stores, the half-life of PCP is believed to be three days.3, 13 Due to the brain’s high lipid content and ion trapping, cerebral levels of PCP may be nine times serum levels, allowing its CNS effects to last from seven hours to as long as seven days in chronic users.17
Gene_expression (levels) of PCP in adipose tissue associated with obesity
6) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.32 Pain Relevance 0.10
Several drugs like diphenhydramine, dextromethorphan, and venlafaxine and its derivatives may cause a urine specimen to test positive for PCP if tests other than gas chromatography/mass spectrophotometry (GS/MS) are used, such as the fluorescence polarization immunoassay or high pressure liquid chromatography.35, 36
Gene_expression (test) of PCP in urine associated with dextromethorphan
7) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.93 Pain Relevance 0.11
In this situation, saliva or gastric contents can be analyzed for PCP.33
Spec (analyzed) Gene_expression (analyzed) of PCP in saliva
8) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.00 Pain Relevance 0.04
Low doses of phencyclidine have produced patterns of metabolic and neurochemical changes in rodent brains that resemble those in brains of schizophrenic patients.24 A typical PCP-induced coma is manifested as an unresponsive patient whose eyes remain open.1, 10
Gene_expression (produced) of PCP in eyes associated with coma and schizophrenia
9) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 2.20 Pain Relevance 0.52
Therefore, a qualitative urine toxicologic screen has become mandatory standard of care for any patient, infant or adult, with altered mental status of unknown etiology.13 Although earlier literature describes three dose-related stages of PCP intoxication, quantitative PCP levels do not correlate well with clinical findings and thus should not guide clinical management.1, 6, 13, 20, 22
Gene_expression (intoxication) of PCP in urine associated with poisoning
10) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.76 Pain Relevance 0.12
Low doses of phencyclidine have produced patterns of metabolic and neurochemical changes in rodent brains that resemble those in brains of schizophrenic patients.24 A typical PCP-induced coma is manifested as an unresponsive patient whose eyes remain open.1, 10
Gene_expression (those) of PCP in eyes associated with coma and schizophrenia
11) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 2.14 Pain Relevance 0.50
Over 50% of adult patients present with the classic toxidrome of PCP intoxication: violent behavior, nystagmus, tachycardia, hypertension, anesthesia, and analgesia.1, 7, 22, 23
Gene_expression (intoxication) of PCP associated with nystagmus, pressure and volume under development, heart rate under development, anesthesia, poisoning and analgesia
12) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.63 Pain Relevance 0.95
In animal experiments PCP-binding antibodies actually increased serum concentrations of PCP, indicating that they simply alter its distribution.16 PCP levels are highest in adipose tissue, and because of its slow, uneven release from lipid stores, the half-life of PCP is believed to be three days.3, 13 Due to the brain’s high lipid content and ion trapping, cerebral levels of PCP may be nine times serum levels, allowing its CNS effects to last from seven hours to as long as seven days in chronic users.17
Gene_expression (levels) of PCP in adipose tissue associated with obesity
13) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.24 Pain Relevance 0.09
Respiratory depression requiring intubation is uncommon in PCP intoxication; however, patients may exhibit irregular breathing, with episodes of both apnea and tachypnea.9, 22 Furthermore, pharyngeal and laryngeal reflexes become hyperactive, and sympathomimetic effects create bronchorrhea, which exacerbate the risk of airway obstruction in an already obtunded patient.9, 22, 27
Gene_expression (intoxication) of PCP in Respiratory associated with depression, airway obstruction, respiratory failure, sleep disorders and poisoning
14) Confidence 0.51 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 2.29 Pain Relevance 0.30
Some examples of therapeutic strategies such as gene or drug delivery systems using stem cell homing show an anti-cancer efficacy, including EGFR antagonist, IL-2, IL-4 cytotoxin, interleukin-13 receptor-directed cytotoxin [32], BMP-1/-2, IFN-?
Gene_expression (/) of BMP-1 in stem cell associated with cancer and antagonist
15) Confidence 0.10 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.80 Pain Relevance 0.12
The expression of the type I procollagen gene was examined by in-situ hybridizations of affected skin with a human sequence-specific complementary DNA (cDNA).
Spec (examined) Gene_expression (expression) of procollagen gene in skin
16) Confidence 0.07 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.92 Pain Relevance 0.08
Since PCP as well exerts
Gene_expression (exerts) of PCP
17) Confidence 0.04 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.50 Pain Relevance 0.22

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