INT22558

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.22
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL3A1) extracellular region (COL3A1)
Anatomy Link Frequency
fibroblasts 2
fascia 1
tendon 1
bursa 1
temporomandibular joints 1
COL3A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.58 Very High Very High Very High
fibrosis 10 98.56 Very High Very High Very High
Pain 19 97.70 Very High Very High Very High
Inflammation 9 96.36 Very High Very High Very High
cytokine 8 93.80 High High
antagonist 1 89.12 High High
Snapping jaw 4 88.84 High High
agonist 1 77.76 Quite High
Clonidine 1 77.04 Quite High
ischemia 4 35.64 Quite Low
Disease Link Frequency Relevance Heat
Rupture 36 99.56 Very High Very High Very High
Eosinophilia 4 98.70 Very High Very High Very High
Fibrosis 22 98.56 Very High Very High Very High
Fasciitis 6 98.34 Very High Very High Very High
Apoptosis 3 98.34 Very High Very High Very High
Disease 252 97.40 Very High Very High Very High
Systemic Sclerosis 8 97.24 Very High Very High Very High
INFLAMMATION 9 96.36 Very High Very High Very High
Contracture 50 95.78 Very High Very High Very High
Syndrome 7 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presence of type III collagen in disc attachments of human temporomandibular joints.
Gene_expression (Presence) of type III collagen in temporomandibular joints
1) Confidence 0.78 Published 1990 Journal Arch. Oral Biol. Section Title Doc Link 2378582 Disease Relevance 0 Pain Relevance 0.08
All genes were found to be regulated in the same direction with either method, however two genes (COL1A1 and COL3A1) did not meet the FC>1.2 criteria (?
Neg (not) Gene_expression (meet) of COL3A1
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0 Pain Relevance 0
Analysis of macromolecular components revealed that type III collagen was mainly present on the collagenous framework of the sheath-like structure.
Gene_expression (present) of type III collagen
3) Confidence 0.52 Published 1996 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 8665306 Disease Relevance 0.24 Pain Relevance 0.24
Increased hybridization signals were detected in the deep dermis and fascia, indicating enhanced expression of the collagen gene.
Gene_expression (expression) of collagen gene in fascia
4) Confidence 0.41 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.86 Pain Relevance 0.08
The temporal association of L-tryptophan use and the development of a scleroderma-like illness in these four patients suggests a causal relation between L-tryptophan or its metabolites and the stimulation of fibroblast collagen gene expression that results in dermal and fascial fibrosis.
Gene_expression (expression) of collagen gene in fibroblast associated with fibrosis and systemic sclerosis
5) Confidence 0.41 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.88 Pain Relevance 0.09
Development of diffuse fasciitis with eosinophilia during L-tryptophan treatment: demonstration of elevated type I collagen gene expression in affected tissues.
Gene_expression (expression) of collagen gene associated with pain, fasciitis and eosinophilia
6) Confidence 0.36 Published 1990 Journal Ann. Intern. Med. Section Title Doc Link 2306063 Disease Relevance 0.98 Pain Relevance 0.16
Increased hybridization signals were detected in the deep dermis and fascia, indicating enhanced expression of the collagen gene.
Gene_expression (expression) of collagen gene in dermis
7) Confidence 0.14 Published 1990 Journal Ann. Intern. Med. Section Abstract Doc Link 2306063 Disease Relevance 0.86 Pain Relevance 0.08
Immunoblotting with specific antibodies showed that granulosa cell membranes express alpha s, alpha i3 alpha i1,2, alpha q,11 and beta subunits.
Gene_expression (express) of alpha i3 alpha in granulosa cell
8) Confidence 0.06 Published 1995 Journal J. Reprod. Fertil. Section Abstract Doc Link 7636809 Disease Relevance 0.12 Pain Relevance 0.12
In the final disease stage, termed the residual phase, nodules regress leaving the tendon-like, inelastic, relatively acellular cords that cause the clinically apparent fixed flexion contractures.23 Normal palmar fascial tissue is primarily composed of type I collagen – in DD, the increased density and decreased apoptosis of fibroblasts, plus an imbalance in matrix metalloproteinase activity, result in excessive type III collagen production.45
Gene_expression (production.45) of type III collagen in fibroblasts associated with metalloproteinase, contracture, apoptosis and disease
9) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 1.31 Pain Relevance 0.15
In the final disease stage, termed the residual phase, nodules regress leaving the tendon-like, inelastic, relatively acellular cords that cause the clinically apparent fixed flexion contractures.23 Normal palmar fascial tissue is primarily composed of type I collagen – in DD, the increased density and decreased apoptosis of fibroblasts, plus an imbalance in matrix metalloproteinase activity, result in excessive type III collagen production.45
Gene_expression (excessive) of type III collagen in tendon associated with metalloproteinase, contracture, apoptosis and disease
10) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 1.31 Pain Relevance 0.14
In bursa samples from patients with ruptures of the rotator cuff, expression of collagen types I and III was enhanced compared with normal controls [16].
Gene_expression (expression) of collagen types I and III in bursa associated with rupture
11) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.66 Pain Relevance 0.22

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