INT2256

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Context Info
Confidence 0.47
First Reported 1976
Last Reported 2007
Negated 3
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.69
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
plasma 1
fat 1
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 4 99.32 Very High Very High Very High
Chronic pancreatitis 20 99.28 Very High Very High Very High
antagonist 3 99.16 Very High Very High Very High
Somatostatin 7 98.68 Very High Very High Very High
tolerance 5 94.08 High High
narcan 3 92.56 High High
opiate 2 91.40 High High
orphanin 4 87.12 High High
anesthesia 2 86.48 High High
imagery 1 77.60 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 20 99.28 Very High Very High Very High
Diabetes Mellitus 14 98.36 Very High Very High Very High
Celiac Disease 8 95.80 Very High Very High Very High
Disease 9 95.48 Very High Very High Very High
Impaired Glucose Tolerance 7 94.72 High High
Body Weight 2 81.00 Quite High
Abdominal Pain 1 76.20 Quite High
Steatorrhea 1 75.00 Quite High
Hyperinsulinism 3 74.32 Quite High
Ulcers 1 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postprandial GIP release and serum insulin levels are not affected by vagotomy, but basal GIP levels are increased after vagotomy.
Neg (not) Regulation (affected) of GIP
1) Confidence 0.47 Published 1979 Journal World J Surg Section Abstract Doc Link 390900 Disease Relevance 0.15 Pain Relevance 0.11
Addition of glucomannan and soya-bean-cotyledon fibre did not affect circulating GIP levels.
Neg (not) Regulation (affect) of GIP
2) Confidence 0.38 Published 1990 Journal Br. J. Nutr. Section Abstract Doc Link 2169302 Disease Relevance 0.46 Pain Relevance 0.32
Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the biological activity of GIP in vivo is still largely unknown.
Regulation (regulating) of GIP
3) Confidence 0.33 Published 2001 Journal Diabetes Section Abstract Doc Link 11423480 Disease Relevance 0 Pain Relevance 0
Response of gastric inhibitory polypeptide (GIP) to test meal in chronic pancreatitis--relationship to endocrine and exocrine insufficiency.
Regulation (Response) of GIP associated with chronic pancreatitis
4) Confidence 0.23 Published 1976 Journal Diabetologia Section Title Doc Link 1001849 Disease Relevance 0.36 Pain Relevance 0.34
Response of gastric inhibitory polypeptide (GIP) to test meal in chronic pancreatitis--relationship to endocrine and exocrine insufficiency.
Regulation (Response) of gastric inhibitory polypeptide associated with chronic pancreatitis
5) Confidence 0.23 Published 1976 Journal Diabetologia Section Title Doc Link 1001849 Disease Relevance 0.36 Pain Relevance 0.34
The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure).
Regulation (response) of gastric inhibitory polypeptide associated with celiac disease, disease and chronic pancreatitis
6) Confidence 0.21 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.69 Pain Relevance 0.09
The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure).
Regulation (response) of GIP associated with celiac disease, disease and chronic pancreatitis
7) Confidence 0.21 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.70 Pain Relevance 0.09
Response of serum levels of gastric inhibitory polypeptide and insulin to sucrose ingestion during long-term application of acarbose.
Regulation (Response) of gastric inhibitory polypeptide
8) Confidence 0.20 Published 1981 Journal Scand. J. Gastroenterol. Section Title Doc Link 7034156 Disease Relevance 0.08 Pain Relevance 0.08
GIP) is not influenced by the NOP receptor antagonist at the concentration of 10(-6) M (-49+/-9%; ns vs.
Neg (not) Regulation (influenced) of GIP associated with antagonist
9) Confidence 0.17 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12137964 Disease Relevance 0 Pain Relevance 0.82
Post-prandial plasma triglycerides, light scattering indices (LSI; an index of post-prandial chylomicronaemia) and paracetamol levels paralleled the integrated GIP responses on both normal and low-fat diets. 4.
Regulation (responses) of GIP in fat associated with paracetamol
10) Confidence 0.16 Published 1988 Journal Br. J. Nutr. Section Abstract Doc Link 3408703 Disease Relevance 0 Pain Relevance 0.22
RESULTS: A significant diminished GIP response was found in the groups of patients with respect to the control group.
Regulation (response) of GIP
11) Confidence 0.16 Published 1996 Journal Regul. Pept. Section Body Doc Link 8988521 Disease Relevance 0.17 Pain Relevance 0
Feedback regulation of glucose-dependent insulinotropic polypeptide (GIP) was studied in a conscious rat model.
Regulation (regulation) of insulinotropic
12) Confidence 0.11 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8059006 Disease Relevance 0.18 Pain Relevance 0.09
In conclusion, lack of GIP amplification of the late-phase plasma insulin response to glucose seems to be a consequence of diabetes mellitus, characterizing most, if not all, forms of diabetes.
Regulation (response) of GIP in plasma associated with diabetes mellitus
13) Confidence 0.04 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557471 Disease Relevance 1.13 Pain Relevance 0.06
We aimed to investigate how assimilation of nutrients affects the postprandial responses of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and to evaluate the effect of pancreatic enzyme substitution (PES) on insulin secretion in patients with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI).
Regulation (affects) of insulinotropic associated with chronic pancreatitis
14) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16954337 Disease Relevance 0.42 Pain Relevance 0.35

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