INT22560

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Context Info
Confidence 0.23
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL3A1) extracellular region (COL3A1)
COL3A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 98.02 Very High Very High Very High
fibrosis 2 79.44 Quite High
Potency 1 60.80 Quite High
spinal inflammation 2 50.00 Quite Low
agonist 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 1 99.02 Very High Very High Very High
Fasciitis 1 98.66 Very High Very High Very High
Systemic Sclerosis 2 94.84 High High
Syndrome 1 94.16 High High
Adhesions 45 92.72 High High
Sleep Disorders 1 92.44 High High
Tinnitus 1 91.96 High High
Low Back Pain 2 90.28 High High
Pressure And Volume Under Development 1 90.24 High High
Exanthema 1 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Development of diffuse fasciitis with eosinophilia during L-tryptophan treatment: demonstration of elevated type I collagen gene expression in affected tissues.
Positive_regulation (elevated) of collagen gene associated with pain, fasciitis and eosinophilia
1) Confidence 0.23 Published 1990 Journal Ann. Intern. Med. Section Title Doc Link 2306063 Disease Relevance 0.98 Pain Relevance 0.16
RESULTS: Significant elevations of antibodies against type II (IgG and IgA classes) and type IV (IgA class) collagens were observed in AS patients, whilst there was no significant elevation of any antibody class against type I or III collagen when compared to controls.
Neg (no) Positive_regulation (elevation) of III collagen
2) Confidence 0.18 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9177925 Disease Relevance 0.09 Pain Relevance 0
These included 57 peptides derived from the sequence of human type III collagen and 9 peptides derived from the cyanogen bromide fragment of bovine type III collagen, ?
Positive_regulation (sequence) of type III collagen
3) Confidence 0.05 Published 2008 Journal Blood Section Abstract Doc Link PMC2602586 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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