INT225601

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncoa6) enzyme binding (Ncoa6) protein complex (Ncoa6)
D0Nrs1 (Mus musculus)
Ncoa6 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 38 5.00 Very Low Very Low Very Low
cytokine 19 5.00 Very Low Very Low Very Low
Inflammation 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 456 93.92 High High
Shock 57 87.36 High High
Congenital Anomalies 19 82.96 Quite High
Microphthalmia 19 71.44 Quite High
Cataract 19 67.84 Quite High
Cancer 133 62.32 Quite High
Breast Cancer 152 47.08 Quite Low
Repression 76 46.08 Quite Low
Colon Cancer 19 44.92 Quite Low
Wound Healing 285 17.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that although the NIF-ID and the NR interaction region of NCoA6(NRC) are in close physical proximity (Figure 2), associations of NIF-1 and NRs with NCoA6(NRC) are not mutually exclusive.
NRs Binding (associations) of NRC
1) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
It is interesting that although the NIF-ID and the NR interaction region of NCoA6(NRC) are in close physical proximity (Figure 2), associations of NIF-1 and NRs with NCoA6(NRC) are not mutually exclusive.
NRs Binding (associations) of NCoA6
2) Confidence 0.04 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The NCoA6(NRC) LxxLL-1 module and surrounding amino acids is very hydrophobic and interacts with virtually all liganded NRs with high affinity.
NRs Binding (interacts) of NCoA6
3) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The NCoA6(NRC) LxxLL-1 module and surrounding amino acids is very hydrophobic and interacts with virtually all liganded NRs with high affinity.
NRs Binding (interacts) of NRC
4) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
NCoA6(ASC-2) associates with the majority of the NRs through LxxLL-1, while LxxLL-2 specifically associates with LXRs.
NRs Binding (associates) of NCoA6
5) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.63 Pain Relevance 0
Thus, like CBP, NCoA6 may act as a transcriptional co-integrator through its interaction with a variety of transcription factors, including the NRs.
NRs Binding (interaction) of NCoA6
6) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.21 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NRs Binding (association) of NRC
7) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In contrast, NCoA6(NRC) contains a single functional LxxLL-1 module that associates with a variety of NRs in vitro and in vivo with high affinity.
NRs Binding (associates) of NRC
8) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NRs Binding (association) of NRC
9) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Since NIF-1 does not directly bind to NRs, its action is likely through its association with a primary coactivator such as NCoA6(NRC).
NRs Neg (not) Binding (bind) of NCoA6
10) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Since NIF-1 does not directly bind to NRs, its action is likely through its association with a primary coactivator such as NCoA6(NRC).
NRs Binding (association) of NCoA6
11) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300 was identified as a coactivator for NRs [Chakravarti et al., 1996] and is considered a transcriptional integrator which is recruited to the NRs and other transcription factors through their association with other coactivators (e.g., the SRCs and NCoA6(NRC)) [Chan and La Thangue, 2001; Chen et al., 1997; Goodman and Smolik, 2000; Mahajan and Samuels, 2000; Tian et al., 2006; Torchia et al., 1997].
NRs Binding (association) of NCoA6
12) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In yeast two-hybrid assays, full-length NCoA6(NRC) interacts with ligand-bound NRs with similar or higher affinity than full-length SRC-1 containing multiple functional LxxLL motifs.
NRs Binding (interacts) of NRC
13) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Barring one initial report with NCoA6(ASC-2), which suggested that NRs interact through a region of NCoA6(ASC-2) (amino acids 586-860) that did not contain any LxxLL motif [Lee et al., 1999], all other studies confirmed that of the two LxxLL motifs in NCoA6, LxxLL-1 is necessary for interaction with a wide spectrum of NRs including TRs, RXRs, RARs, GR, ERs, VDR and the PPARs [Caira et al., 2000; Ko et al., 2000; Mahajan and Samuels, 2000].
NRs Binding (interact) of NCoA6
14) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In contrast, NCoA6(NRC) contains a single functional LxxLL-1 module that associates with a variety of NRs in vitro and in vivo with high affinity.
NRs Binding (associates) of NCoA6
15) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In yeast two-hybrid assays, full-length NCoA6(NRC) interacts with ligand-bound NRs with similar or higher affinity than full-length SRC-1 containing multiple functional LxxLL motifs.
NRs Binding (interacts) of NCoA6
16) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, the LxxLL-1 module of NCoA6(NRC) embedded in AD2 influences not only the association of NCoA6(NRC) with NRs, but also the activation potential of AD2.
NRs Binding (association) of NRC
17) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Thus, the LxxLL-1 module of NCoA6(NRC) embedded in AD2 influences not only the association of NCoA6(NRC) with NRs, but also the activation potential of AD2.
NRs Binding (association) of NCoA6
18) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Mutation of LVNLL (LxxLL-1) to AVNAA or to AVNAL or to LVAAA abrogated the association of NCoA6 with NRs in vitro [Caira et al., 2000; Ko et al., 2000; Mahajan and Samuels, 2000] and in vivo [Mahajan and Samuels, 2000].
NRs Binding (association) of NCoA6
19) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

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