INT22566

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.06
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tcf21)
Anatomy Link Frequency
nerve 1
limb 1
kidney 1
Tcf21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 57 100.00 Very High Very High Very High
withdrawal 23 99.26 Very High Very High Very High
Paracetamol 2 98.12 Very High Very High Very High
Perioperative pain 4 94.40 High High
positron emission tomography 41 93.08 High High
anesthesia 9 92.60 High High
lidocaine 5 91.64 High High
chemokine 103 91.20 High High
Pain 31 90.64 High High
Preemptive analgesia 5 89.68 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 40 100.00 Very High Very High Very High
Cancer 8 99.04 Very High Very High Very High
Nociception 19 96.24 Very High Very High Very High
Post Operative Pain 4 94.40 High High
Pneumoperitoneum 3 93.48 High High
Pain 44 90.64 High High
Necrosis 22 88.88 High High
Injury 19 88.28 High High
Hemorrhage 1 87.84 High High
Demyelinating Disease 48 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POD activity is highly induced in both hepatic and extrahepatic tissues of the rat following treatment with polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (MC).
Positive_regulation (induced) of POD
1) Confidence 0.65 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 2306262 Disease Relevance 0 Pain Relevance 0.09
Animals were sacrificed on 1st(POD1) and 8th (POD8) postoperative day.
Positive_regulation (sacrificed) of POD1 associated with cancer
2) Confidence 0.50 Published 2006 Journal Surg Endosc Section Abstract Doc Link 17031748 Disease Relevance 0.76 Pain Relevance 0.09
Although, affected (left) limb performance on both CST (6.8-fold increase in trs on POD 1 compared to baseline) and MST (100% decrease in tas on POD 1 compared to baseline) was markedly altered by rMCAo, CST performance declined bilaterally, and no significant differences in the ratio of affected (left) and unaffected (right) limb performance between sham-operated and rMCAo animals were observed at any time point.
Positive_regulation (increase) of POD 1 in limb
3) Confidence 0.49 Published 2006 Journal J. Neurosci. Methods Section Abstract Doc Link 16476486 Disease Relevance 0.20 Pain Relevance 0.19
In untreated rats, microsomal POD activity is detectable in both the liver and lung, but not in the small intestine or the kidney.
Neg (not) Positive_regulation (detectable) of POD in kidney
4) Confidence 0.43 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 2306262 Disease Relevance 0 Pain Relevance 0.10
Signs of acute rejection increased until POD 4.
Positive_regulation (increased) of POD
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669171 Disease Relevance 0.40 Pain Relevance 0.36
As with CCR2 expression in sensory neurons, CCR5 mRNA transcript levels were strongly increased in many sensory neurons ipsilateral and contralateral to the nerve injury at POD14 (Fig. 5D).
Positive_regulation (increased) of POD14 in nerve associated with nervous system injury
6) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.71 Pain Relevance 0.42
Unlike in other studies [32-34], preemptive bupivacaine did not prevent a decrease in withdrawal thresholds early on, however it did increase thresholds after POD 9 in this study.
Positive_regulation (increase) of POD 9 associated with withdrawal
7) Confidence 0.21 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935977 Disease Relevance 0.79 Pain Relevance 1.47
Compared to that of Sham-Saline group, the level of anti-phosphorylated NR1 (pNR1) was significantly increased in SNL-Saline group on POD 7 (P < 0.05 compared to Sham-Saline) (Fig 2).
Positive_regulation (increased) of POD associated with spinal nerve ligature
8) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.21 Pain Relevance 1.03

General Comments

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