INT2257

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Context Info
Confidence 0.74
First Reported 1976
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 11.08
Pain Relevance 7.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
blood 2
ileum 1
fat 1
duodenum 1
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 21 100.00 Very High Very High Very High
tolerance 17 99.96 Very High Very High Very High
Chronic pancreatitis 38 99.84 Very High Very High Very High
Enkephalin 20 99.40 Very High Very High Very High
narcan 5 98.40 Very High Very High Very High
Opioid 4 97.36 Very High Very High Very High
opioid receptor 1 96.68 Very High Very High Very High
abdominal pain 1 96.16 Very High Very High Very High
substance P 3 95.76 Very High Very High Very High
tetrodotoxin 2 94.96 High High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 21 99.96 Very High Very High Very High
Pancreatitis 43 99.84 Very High Very High Very High
Hyperinsulinism 4 99.52 Very High Very High Very High
Disease 13 98.92 Very High Very High Very High
Steatorrhea 9 98.68 Very High Very High Very High
Celiac Disease 15 98.60 Very High Very High Very High
Diabetes Mellitus 25 97.84 Very High Very High Very High
Abdominal Pain 1 96.16 Very High Very High Very High
Hypoglycemia 3 95.24 Very High Very High Very High
Cystic Fibrosis 3 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical aspects of GIP secretion.
Localization (secretion) of GIP
1) Confidence 0.74 Published 1982 Journal Acta Diabetol Lat Section Title Doc Link 6280423 Disease Relevance 0.76 Pain Relevance 0.12
The impaired absorption of the food-stuffs and the defective feed-back regulation of GIP secretion by insulin are the major causes of these variations.
Localization (secretion) of GIP
2) Confidence 0.74 Published 1982 Journal Acta Diabetol Lat Section Abstract Doc Link 6280423 Disease Relevance 0.82 Pain Relevance 0.14
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution.
Localization (secretion) of GIP associated with steatorrhea
3) Confidence 0.73 Published 1980 Journal Diabetologia Section Title Doc Link 6997121 Disease Relevance 0.50 Pain Relevance 0.13
Vagal stimulation (7 V, 10 Hz, 5 ms) inhibited GIP-stimulated SLI release.
Localization (release) of GIP-stimulated SLI associated with somatostatin
4) Confidence 0.70 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.14
In conclusion, in addition to luminal stimulation of nutrients, a cholinergic impulse as well as peptidergic mediators (among them possibly GIP and GRP) may have an impact on postprandial GLP-1 secretion from the rat ileum.
Localization (secretion) of GIP in ileum
5) Confidence 0.68 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7490533 Disease Relevance 0 Pain Relevance 0.28
In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release.
Localization (release) of GIP in fat associated with chronic pancreatitis
6) Confidence 0.68 Published 1976 Journal Diabetologia Section Abstract Doc Link 1001849 Disease Relevance 0.33 Pain Relevance 0.34
To a lesser degree, gastric acid secretion, gastric emptying and vagal control may also influence GIP secretion.
Localization (secretion) of GIP
7) Confidence 0.65 Published 1982 Journal Acta Diabetol Lat Section Abstract Doc Link 6280423 Disease Relevance 0.76 Pain Relevance 0.13
Intraarterial infusion of glucose-dependent insulinotropic peptide (GIP) over the concentration range 0.25-1 nM evoked a dose-dependent release of GLP-1, with a maximal response of 350% of the basal value.
Localization (release) of GIP
8) Confidence 0.61 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.29
The influence of impaired digestion on nutrient induced release of gastric inhibitory polypeptide (GIP) and insulin have been investigated in patients with chronic pancreatitis.
Localization (release) of gastric inhibitory polypeptide associated with chronic pancreatitis
9) Confidence 0.56 Published 1980 Journal Diabetologia Section Abstract Doc Link 6997121 Disease Relevance 0.41 Pain Relevance 0.13
The influence of impaired digestion on nutrient induced release of gastric inhibitory polypeptide (GIP) and insulin have been investigated in patients with chronic pancreatitis.
Localization (release) of GIP associated with chronic pancreatitis
10) Confidence 0.56 Published 1980 Journal Diabetologia Section Abstract Doc Link 6997121 Disease Relevance 0.41 Pain Relevance 0.13
Galanin also inhibited insulin release in response to glucose administered with GIP; this effect was due largely to inhibition of the glucose-stimulated component since galanin did not inhibit GIP-stimulated insulin release.
Localization (release) of GIP-stimulated
11) Confidence 0.55 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0.03
The present study was designed to determine the effects of intravenously administered galanin or gastrin-releasing peptide (GRP) on glucose- and/or glucose-dependent insulinotropic peptide (GIP)-stimulated insulin release in the anaesthetized rat.
Localization (release) of GIP
12) Confidence 0.55 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0
The present study was designed to determine the effects of intravenously administered galanin or gastrin-releasing peptide (GRP) on glucose- and/or glucose-dependent insulinotropic peptide (GIP)-stimulated insulin release in the anaesthetized rat.
Localization (release) of insulinotropic
13) Confidence 0.55 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0
GRP inhibited glucose-stimulated insulin responses, and the insulin responses to glucose plus GIP; unlike galanin, GRP inhibited both glucose- and GIP-stimulated insulin release.
Localization (release) of GIP-stimulated
14) Confidence 0.55 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0.04
This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
Localization (release) of GIP in duodenum
15) Confidence 0.55 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.74 Pain Relevance 0.15
Postprandial GIP release and serum insulin levels are not affected by vagotomy, but basal GIP levels are increased after vagotomy.
Localization (release) of GIP
16) Confidence 0.54 Published 1979 Journal World J Surg Section Abstract Doc Link 390900 Disease Relevance 0.15 Pain Relevance 0.11
In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed.
Localization (release) of GIP associated with chronic pancreatitis
17) Confidence 0.48 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.83 Pain Relevance 0.18
It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients.
Localization (release) of GIP
18) Confidence 0.48 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.86 Pain Relevance 0.17
The effect of dietary modification and hyperglycaemia on gastric emptying and gastric inhibitory polypeptide (GIP) secretion.
Localization (secretion.) of GIP
19) Confidence 0.46 Published 1988 Journal Br. J. Nutr. Section Title Doc Link 3408703 Disease Relevance 0 Pain Relevance 0.15
The failure of sugar-beet fibre to reduce post-prandial insulin secretion despite improved glucose tolerance may be due to the observed increased secretion of GIP.
Spec (observed) Localization (secretion) of GIP associated with tolerance and impaired glucose tolerance
20) Confidence 0.43 Published 1990 Journal Br. J. Nutr. Section Abstract Doc Link 2169302 Disease Relevance 0.43 Pain Relevance 0.27

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