INT225758

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.18
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocyte 2
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 45 98.68 Very High Very High Very High
cytokine 9 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 45 98.68 Very High Very High Very High
Aging 39 97.56 Very High Very High Very High
Chondrocalcinosis 9 97.04 Very High Very High Very High
Calcification 138 96.92 Very High Very High Very High
Metabolic Disorder 3 93.48 High High
Disease 24 70.12 Quite High
Osteoporosis 12 8.52 Low Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, excess extracellular PPi also may result from heightened release of intracellular PPi via increased ANK expression in OA and abnormal ANK function in familial chondrocalcinosis, as well as from deficient activity of pyrophosphatases (such as TNAP and possibly inorganic pyrophosphatase) in certain primary metabolic disorders.
Localization (release) of PPi associated with chondrocalcinosis, metabolic disorder and osteoarthritis
1) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.40 Pain Relevance 0.19
expression and responsiveness, which drives PPi generation and release mediated via NPP1 and ANK, and diminished responsiveness to IGF-I, which normally suppresses elevation of chondrocyte extracellular PPi.
Localization (elevation) of PPi in chondrocyte
2) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.76 Pain Relevance 0.11
expression and responsiveness, which drives PPi generation and release mediated via NPP1 and ANK, and diminished responsiveness to IGF-I, which normally suppresses elevation of chondrocyte extracellular PPi.
Localization (release) of PPi in chondrocyte
3) Confidence 0.07 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.02 Pain Relevance 0.15

General Comments

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