INT225763

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.56
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cilp) extracellular region (Cilp) proteinaceous extracellular matrix (Cilp)
molecular_function (Cilp)
Anatomy Link Frequency
cartilage 2
Cilp (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 30 82.28 Quite High
cytokine 6 14.92 Low Low
depression 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 26 99.72 Very High Very High Very High
Calcification 92 94.00 High High
Osteoarthritis 30 82.28 Quite High
Syndrome 2 81.60 Quite High
Parkinson's Disease 2 69.64 Quite High
Disease 16 56.80 Quite High
Hyperostosis 2 38.08 Quite Low
Congenital Anomalies 6 8.20 Low Low
Osteoporosis 8 5.00 Very Low Very Low Very Low
Chondrocalcinosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We refuted this work [52], and in so doing, we demonstrated that increased expression of one of 2 CILP isoforms (CILP-1) in aging cartilage interferes with the regulatory effects of IGF-I on PPi metabolism, thereby promoting increased extracellular PPi and cartilage calcification.


Gene_expression (expression) of CILP in cartilage associated with calcification and aging
1) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.78 Pain Relevance 0.08
We refuted this work [52], and in so doing, we demonstrated that increased expression of one of 2 CILP isoforms (CILP-1) in aging cartilage interferes with the regulatory effects of IGF-I on PPi metabolism, thereby promoting increased extracellular PPi and cartilage calcification.


Gene_expression (expression) of CILP in cartilage associated with calcification and aging
2) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.78 Pain Relevance 0.08

General Comments

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