INT225767

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.51
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ank) plasma membrane (Ank)
Anatomy Link Frequency
articular cartilage 1
Ank (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 30 97.76 Very High Very High Very High
cytokine 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 92 98.76 Very High Very High Very High
Chondrocalcinosis 6 98.20 Very High Very High Very High
Osteoarthritis 30 97.76 Very High Very High Very High
Syndrome 2 92.24 High High
Aging 26 84.48 Quite High
Disease 16 76.08 Quite High
Hyperostosis 2 73.76 Quite High
Osteoporosis 8 51.16 Quite High
Parkinson's Disease 2 50.64 Quite High
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the apparent co-dependent function of ANK and NPP1 to raise extracellular PPi [34] is the remarkable similarity in the consequences of deficient ANK and PC-1 function in vivo.
Negative_regulation (deficient) of ANK
1) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.92 Pain Relevance 0.06
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Negative_regulation (defective) of ANK in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
2) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.59 Pain Relevance 0.28

General Comments

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