INT225768

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 8.11
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Enpp2) extracellular region (Enpp2)
Anatomy Link Frequency
mammary gland 1
thyroid 1
osteoclasts 1
adipocyte 1
Enpp2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 96.96 Very High Very High Very High
Neuropathic pain 14 95.88 Very High Very High Very High
Potency 15 78.28 Quite High
cytokine 11 66.16 Quite High
Pain 10 29.08 Quite Low
adenocard 2 7.88 Low Low
antagonist 21 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 279 99.48 Very High Very High Very High
Cancer 432 98.56 Very High Very High Very High
Glioblastoma 6 97.92 Very High Very High Very High
Targeted Disruption 40 97.10 Very High Very High Very High
Rheumatoid Arthritis 6 96.96 Very High Very High Very High
Metastasis 353 96.84 Very High Very High Very High
Neuroblastoma 7 96.72 Very High Very High Very High
Lung Cancer 12 95.92 Very High Very High Very High
Neuropathic Pain 16 95.88 Very High Very High Very High
Chronic Hepatitis 6 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, in addition to the predominant role of autotaxin/LPA track in the carcinogenesis of breast cancers our results demonstrated that activation of autotaxin/LPA axis in breast cancer cells controlled the progression of osteolytic bone metastases by stimulating directly both cancer cells and osteoclasts.
Positive_regulation (activation) of autotaxin in osteoclasts associated with cancer, breast cancer and metastasis
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.86 Pain Relevance 0
A recent study showed that transgenic overexpression of autotaxin or LPA1-3 receptors in the mouse mammary gland is sufficient to initiate breast cancers in mice, demonstrating that activation of the autotaxin/LPA track induces carcinogenesis [25].
Positive_regulation (activation) of autotaxin in mammary gland associated with targeted disruption and breast cancer
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.27 Pain Relevance 0
We found that even if the absolute median values of ENPP2 transcript levels were consistently increased together with the characteristics of poor prognostics, the differences did not reach statistically significance.
Positive_regulation (increased) of ENPP2
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.01 Pain Relevance 0.03
To determine whether the effect of autotaxin was due to its lysoPLD activity, we used a ?
Spec (whether) Positive_regulation (effect) of autotaxin
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.49 Pain Relevance 0.07
Intriguingly, upregulation of autotaxin gene was reported in a large variety of cancers such as glioblastoma [19], aggressive neuroblastoma [20], non small cell lung cancer [21], uveal melanoma associated with poor prognosis [22], thyroid carcinoma [23], hepatocellular carcinoma with metastases [24], and breast cancer [16].
Positive_regulation (upregulation) of autotaxin gene in thyroid associated with lung cancer, breast cancer, hepatocellular cancer, skin cancer, metastasis, neuroblastoma, thyroid neoplasm, cancer and glioblastoma
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.61 Pain Relevance 0.12
A link between increased lysoPLD activity and the formation of LPA was found in various pathologies such as rheumatoid arthritis [10], neuropathic pain [11], chronic hepatitis C [12] and adipocyte insulin-resistance in obesity [13].
Positive_regulation (increased) of lysoPLD in adipocyte associated with chronic hepatitis, obesity, neuropathic pain and rheumatoid arthritis
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.13 Pain Relevance 0.14
The secretion of NPP2 by multiple tissues, and NPP2 accumulation in extracellular fluids, allows NPP2, in large part via lysophospholipase D activity, to exert a variety of biologically significant effects on cell growth, differentiation, adhesion, and migration, translated into functional effects in angiogenesis, tumor metastasis, and embryonic development [4, 13–15].
Positive_regulation (accumulation) of NPP2 associated with metastasis and adhesions
7) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.33 Pain Relevance 0
Ten years after its original discovery, ATX was identified as a lysophospholipase D responsible for the production of LPA in serum (Umezu-Goto et al., 2002; Tokumura et al., 2002a).
Positive_regulation (responsible) of lysophospholipase D
8) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.35 Pain Relevance 0

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