INT225769

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 3
Total Number 16
Disease Relevance 16.67
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Enpp2) extracellular region (Enpp2)
Anatomy Link Frequency
4T1 8
mammary gland 4
chondrocytes 2
bone tissue 2
fibroblasts 2
Enpp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 26 91.68 High High
rheumatoid arthritis 14 90.76 High High
Spinal cord 39 86.32 High High
Potency 28 83.84 Quite High
Hyperalgesia 3 68.00 Quite High
allodynia 5 66.64 Quite High
antagonist 14 63.16 Quite High
Thermal hyperalgesia 2 61.60 Quite High
cytokine 17 40.16 Quite Low
spinal dorsal horn 5 38.20 Quite Low
Disease Link Frequency Relevance Heat
Breast Cancer 644 100.00 Very High Very High Very High
Targeted Disruption 57 99.98 Very High Very High Very High
Cancer 952 99.92 Very High Very High Very High
Disease 23 99.80 Very High Very High Very High
Skin Cancer 28 99.24 Very High Very High Very High
Metastasis 799 99.12 Very High Very High Very High
Hypercalcemia 84 98.04 Very High Very High Very High
Hepatocellular Cancer 14 96.40 Very High Very High Very High
Calcification 46 95.16 Very High Very High Very High
Thyroid Neoplasm 14 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our results indicated that increased expression of autotaxin by MDA-B02 cells enhanced the formation of osteolytic bone metastases.


Positive_regulation (increased) of Gene_expression (expression) of autotaxin associated with metastasis
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.93 Pain Relevance 0.04
This confirms previous reports indicating that expression of autotaxin is increased in tumors compared to normal tissues of origin [26].
Positive_regulation (increased) of Gene_expression (expression) of autotaxin associated with cancer
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.37 Pain Relevance 0
We observed that silencing autotaxin expression did not alter the growth of primary tumors since there was no significant difference in the size of 4T1-siATX tumors, as compared to those of 4T1-sbATX and parental tumors (Figure 6A).
Positive_regulation (silencing) of Gene_expression (expression) of autotaxin in 4T1 associated with cancer
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.24 Pain Relevance 0
Forced expression of autotaxin in human breast cancer MDA-B02 cells increased the formation of osteolytic bone metastases in mice, whereas knockdown expression of endogenous autotaxin in mouse mammary tumor 4T1 cells decreased the extent of osteolytic lesions.
Positive_regulation (increased) of Gene_expression (expression) of autotaxin in 4T1 associated with cancer, breast cancer and metastasis
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.80 Pain Relevance 0
We observed that the expression of ENPP2 normalized to the genes encoding ribosomal protein L32 (L32) or TATA-box binding protein (TBP, data not shown), was not significantly modified in patients with bone or soft tissue metastases at the time of diagnosis, as compared with non-metastatic patients (Figure 7).
Positive_regulation (normalized) of Gene_expression (expression) of ENPP2 associated with metastasis
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.16 Pain Relevance 0
A recent study showed that transgenic overexpression of autotaxin or LPA1-3 receptors in the mouse mammary gland is sufficient to initiate breast cancers in mice, demonstrating that activation of the autotaxin/LPA track induces carcinogenesis [25].
Positive_regulation (overexpression) of Gene_expression (overexpression) of autotaxin in mammary gland associated with targeted disruption and breast cancer
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.23 Pain Relevance 0
In contrast, using transwell migration chambers coated with Matrigel™, we observed that silencing autotaxin expression inhibited FBS-driven invasion of 4T1-siATX cells (Figure 4E).
Positive_regulation (silencing) of Gene_expression (expression) of autotaxin in 4T1
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.37 Pain Relevance 0
De novo autotaxin expression enhances in vivo MDA-B02 bone metastasis formation
Positive_regulation (enhances) of Gene_expression (expression) of autotaxin associated with metastasis
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.65 Pain Relevance 0.03
Expression of ENPP2 was detected among the set of genes that are specifically upregulated in rat bone tissue under permanent infusion with PTH(1–34) fragment [35].
Positive_regulation (upregulated) of Gene_expression (Expression) of ENPP2 in bone tissue
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.23 Pain Relevance 0
Additionally, we found that 4T1 cells expressed the autotaxin transcript and protein (Figure 4A and 4C), accounting for the secretion of an enzymatically active autotaxin protein (Figure 4C).
Positive_regulation (accounting) of Gene_expression (expressed) of autotaxin transcript in 4T1
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.78 Pain Relevance 0.03
We analyzed the expression of the autotaxin expressing gene (ENNP2) by real time quantitative PCR in a series of 167 breast tumor biopsies from patients without (n?
Spec (analyzed) Positive_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of autotaxin associated with breast cancer
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.25 Pain Relevance 0
This suggested that autotaxin expression would not be predictive for both the progression and metastatic dissemination of breast cancer tumors.
Neg (not) Positive_regulation (predictive) of Gene_expression (expression) of autotaxin associated with cancer and breast cancer
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.85 Pain Relevance 0
MMTV-atx transgenic mice with specifically increased expression of autotaxin in the mammary gland showed an increased in the incidence of spontaneous mammary tumors over a two-year period, illustrating the pro-oncogenic function of autotaxin [25].
Positive_regulation (increased) of Gene_expression (expression) of autotaxin in mammary gland associated with targeted disruption and cancer
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.85 Pain Relevance 0.10
Increased expression of autotaxin was shown to correlate with increased invasiveness of breast cancer cells [16] and was found to enhance the metastatic potential of ras-transformed 3T3 fibroblasts [17].
Positive_regulation (Increased) of Gene_expression (expression) of autotaxin in fibroblasts associated with breast cancer
14) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.50 Pain Relevance 0.14
However, no significant increase was observed in the absence of rATX.
Neg (no) Positive_regulation (increase) of Neg (absence) Gene_expression (absence) of rATX
15) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.25 Pain Relevance 0.40
Correspondingly, we have observed that direct expression of NPP2 did not increase extracellular PPi in chondrocytes, under conditions in which NPP2 did stimulate both alkaline phosphatase and increased calcification [12].
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of NPP2 in chondrocytes associated with calcification
16) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox