INT22577

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Context Info
Confidence 0.50
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.49
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 4
neurons 2
ganglion 2
tubules 2
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 4 99.12 Very High Very High Very High
sodium channel 1 85.68 High High
tetrodotoxin 1 83.76 Quite High
methotrexate 50 74.00 Quite High
cytokine 39 57.76 Quite High
Inflammation 138 57.36 Quite High
Nerve growth factor 17 43.32 Quite Low
chemokine 5 34.28 Quite Low
Neurotransmitter 5 30.16 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 100.00 Very High Very High Very High
Periodontitis 60 99.98 Very High Very High Very High
Headache 4 99.12 Very High Very High Very High
Disease 15 87.60 High High
Targeted Disruption 7 80.40 Quite High
Adhesions 23 76.88 Quite High
Infection 16 62.72 Quite High
Alveolar Bone Loss 14 60.84 Quite High
INFLAMMATION 146 57.36 Quite High
Enteritis 17 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of p65 in ganglion explants increased by 40-100% when the cultures were treated with the depolarizing agents, veratridine or high potassium.
Positive_regulation (increased) of Gene_expression (expression) of p65 in ganglion associated with ganglion cysts
1) Confidence 0.50 Published 1990 Journal J. Neurobiol. Section Abstract Doc Link 2307976 Disease Relevance 0.10 Pain Relevance 0.13
Expression of SytI in sympathetic neurons has been shown to be induced by BMP4 [27], and BMP4 signaling is known to be mediated by Smad proteins and MAPKs [57,58].
Positive_regulation (induced) of Gene_expression (Expression) of SytI in neurons
2) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
A significant increase in nuclear content of p65, an indicator of NF-kappaB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin.
Positive_regulation (increase) of Gene_expression (activation) of p65 in nucleus
3) Confidence 0.34 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.34 Pain Relevance 0.33
The p65 expression was increased in the endothelium, smooth muscle cells (Fig. 22), as well as in the vessel wall, infiltrated cells, glomeruli, and tubules (data not shown) of dTGR kidneys.
Positive_regulation (increased) of Gene_expression (expression) of p65 in tubules
4) Confidence 0.18 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.16 Pain Relevance 0
Hypericum treatment significantly prevented the periodontitis-mediated NF-kB p65 expression (Figure 3b, b1).
Positive_regulation (mediated) of Gene_expression (expression) of p65 associated with periodontitis
5) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.34 Pain Relevance 0
In addition, periodontitis caused a significant increase in the NF-kB p65 levels in the nuclear fractions from of gingivomucosal tissues from operated rats (Figure 3b, b1) compared to the of gingivomucosal tissues from the contralateral side (Figure 3b, b1).
Positive_regulation (increase) of Gene_expression (levels) of p65 associated with periodontitis
6) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.43 Pain Relevance 0
LPS stimulation led to an increase in p65 levels in the nucleus, while treatment of 1.curcumin or SB restrained this effect (Fig. 10).
Positive_regulation (increase) of Gene_expression (levels) of p65 in nucleus
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.12 Pain Relevance 0.20

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