INT225771

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.68
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
ear 2
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 85.04 High High
Inflammation 14 56.96 Quite High
cytokine 15 55.92 Quite High
Osteoarthritis 45 49.68 Quite Low
depression 6 46.08 Quite Low
spinal inflammation 3 39.04 Quite Low
chemokine 33 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 29 100.00 Very High Very High Very High
Calcification 138 99.08 Very High Very High Very High
Metaplasia 3 97.08 Very High Very High Very High
Aging 39 95.80 Very High Very High Very High
Diabetes Mellitus 6 95.52 Very High Very High Very High
Increased Venous Pressure Under Development 4 94.60 High High
Edema 19 94.24 High High
Hyperostosis 3 91.88 High High
INFLAMMATION 17 84.64 Quite High
Renal Insufficiency 3 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not yet known if NPP1 expression is depressed or absent in ttw/ttw mice, or if the ttw mutation, like many of the NPP1 mutations seen in humans with GACI, critically impairs catalytic activity, putatively by interfering with substrate binding.
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of NPP1
1) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.72 Pain Relevance 0.06
Therefore, acquired regional and systemic decrements in NPP1 and ANK expression and extracellular PPi could contribute to intra-arterial chondroosseous metaplasia and calcification in aging, diabetes mellitus, and atherosclerosis.
Negative_regulation (decrements) of Gene_expression (expression) of NPP1 associated with calcification, aging, diabetes mellitus, metaplasia and increased venous pressure under development
2) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.12 Pain Relevance 0
The initial implication of NPP1 deficiency in spontaneous pathologic soft tissue calcification was in ‘tiptoe walking’ ttw/ttw mice, which are homozygous for a spontaneous nonsense mutation that encodes for a stop codon at tyrosine 568, a position 3?
Negative_regulation (implication) of Gene_expression (deficiency) of NPP1 associated with calcification
3) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.79 Pain Relevance 0
However, when the sensitizing dose of DNP-specific IgE was reduced to 50 ng/ear, the PCA reactions in CCRL2 KO mice were significantly impaired compared with those in WT mice (42.2 ± 2.8 vs. 24.9 ± 2.7 × 10?
Negative_regulation (impaired) of Gene_expression (reactions) of PCA in ear associated with anaphylaxis
4) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 1.05 Pain Relevance 0.07

General Comments

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