INT225772

Context Info Confidence 0.62 First Reported 2006 Last Reported 2006 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.60 Pain Relevance 0.40

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)

Anatomy Link Frequency chondrocyte 2 Enpp1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 6 99.76 Inflammation 4 97.28 Osteoarthritis 30 89.52 depression 4 86.40 spinal inflammation 2 79.36 adenocard 4 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 97.28 Calcification 92 95.68 Congenital Anomalies 6 92.80 Aging 26 91.44 Disease 16 90.64 Osteoarthritis 30 89.52 Depression 4 86.40 Low Back Pain 2 79.36 Hyperostosis 2 59.28 Syndrome 2 37.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It will be of interest to see if the implicated NPP1 sequence variants affect NPP1 expression and function.

Spec (implicated) Regulation (affect) of Gene_expression (expression) of NPP1

1) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.96 Pain Relevance 0.26

Physiologic chondrocyte PPi metabolism is regulated in part by growth factor and cytokine regulatory effects on chondrocyte NPP1 expression.

Regulation (effects) of Gene_expression (expression) of NPP1 in chondrocyte associated with cytokine

2) Confidence 0.27 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

This test has worked.