INT225775

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.49
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
chondrocytes 1
lumen 1
Enpp1 (Mus musculus)
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 45 96.60 Very High Very High Very High
cytokine 9 68.72 Quite High
depression 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 138 99.32 Very High Very High Very High
Osteoarthritis 45 96.60 Very High Very High Very High
Aging 39 96.20 Very High Very High Very High
Chondrocalcinosis 9 95.84 Very High Very High Very High
Disease 24 88.84 High High
Congenital Anomalies 9 82.56 Quite High
Metabolic Disorder 3 48.48 Quite Low
Osteoporosis 12 27.24 Quite Low
Depression 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPP1 not only directly induces elevated PPi but also matrix calcification by chondrocytes in vitro.
NPP1 Positive_regulation (induces) of PPi in chondrocytes associated with calcification
1) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.67 Pain Relevance 0.28
Critical to support of extracellular PPi is apparent direct PPi transport by the multiple-pass transmembrane protein ANK [41], which makes a major contribution to moving to the movement into the extracellular space of intracellular PPi, including the fraction of intracellular PPi generated by NPP1 [34].


NPP1 Positive_regulation (generated) of PPi
2) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0.11
In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].
NPP1 Positive_regulation (increase) of PPi in lumen
3) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.33 Pain Relevance 0.06

General Comments

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