INT225775

Context Info Confidence 0.06 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.49 Pain Relevance 0.44

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)

Anatomy Link Frequency chondrocytes 1 lumen 1 Enpp1 (Mus musculus) Ppi-rs (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 45 96.60 cytokine 9 68.72 depression 6 5.00 Inflammation 6 5.00 adenocard 6 5.00 spinal inflammation 3 5.00

Disease Link Frequency Relevance Heat Calcification 138 99.32 Osteoarthritis 45 96.60 Aging 39 96.20 Chondrocalcinosis 9 95.84 Disease 24 88.84 Congenital Anomalies 9 82.56 Metabolic Disorder 3 48.48 Osteoporosis 12 27.24 Depression 6 5.00 INFLAMMATION 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NPP1 not only directly induces elevated PPi but also matrix calcification by chondrocytes in vitro.

NPP1 Positive_regulation (induces) of PPi in chondrocytes associated with calcification

1) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.67 Pain Relevance 0.28

Critical to support of extracellular PPi is apparent direct PPi transport by the multiple-pass transmembrane protein ANK [41], which makes a major contribution to moving to the movement into the extracellular space of intracellular PPi, including the fraction of intracellular PPi generated by NPP1 [34].

NPP1 Positive_regulation (generated) of PPi

2) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0.11

In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].

NPP1 Positive_regulation (increase) of PPi in lumen

3) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.33 Pain Relevance 0.06

General Comments

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